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Paper Information

Title: 

IMMUNOLOGICAL LONG - TERM EFFECTS OF SULFUR MUSTARD POISONING IN IRANIAN VETERANS

Type: SPEECH
Author(s): HEFAZI M.,BALALIMOUD M.,MAHMOUDI M.,RASTIN M.,TABASI N.A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF TOXICOLOGY
Type of Seminar:  CONGRESS
Sponsor:  SOCIETY OF TOXICOLOGY
Date:  2004Volume 8
 
 
Abstract: 

Sulfur mustard (SM) is an alkylating chemical agent that was widely used against Iranian troops during the Iran-Iraq war. One of its major toxic effects has been severe suppression of the immune system years after exposure. It was thus aimed to study these immunological delayed toxic effects in Iranian veterans. Forty SM intoxicated veterans who had a history of acute SM poisoning 16-20 years ago and a control group consisted of 35 healthy individuals were studied. Immune system cells have been evaluated using flowcytometry (FACS calibur, Becton Dickinson, U.S.A). Serum immunoglobulins (IgA, IgG, IgM, and IgE), C3 and C4 levels were also measured. Flowcytometric analysis of CD16+56 positive (NK) cells indicated that the percentage of these cells is significantly lower in patients (9.82%) than in the control group (14.66%) (P<0.05).The percentage of CD3+ lymphocytes was significantly higher in patients (70.59%) than in the control group (64.74%) (P<0.05) There were no major differences between the two groups concerning CD4+, CD8+, and CD19+ cells. While serum IgA, IgG, IgE, and C4 levels didn't show any significant differences, IgM and C3 levels where noticeably higher in the patients compared with the control group (P<0.05). SM poisoning in the long run results in impairment of both cellular and humoral immunity and particularly the natural killer (NK) cells. This could be the major cause of increased risk of recurrent infections and malignancies in patients with heavy exposure to this chemical agent.

 
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