Paper Information

Title: 

EFFECT OF ETHANOL ON THE FUNCTION OF CHICK BIVENTER CERVICES NERVE- MUSCLE PREPARATION: A METHODOLOGICAL CONSIDERATION AND AN INTERESTING OBSERVATION

Type: SPEECH
Author(s): POURHEYDARI G.,SHAHRIARY A.,KHODAEI N.,JAMALI A.,PIRZAD G.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF TOXICOLOGY
Type of Seminar:  CONGRESS
Sponsor:  SOCIETY OF TOXICOLOGY
Date:  2004Volume 8
 
 
Abstract: 

Apart from the fact that effect of ethanol on skeletal muscle, such as alcoholic myopathy, is a research field of interest, it frequently used as vehicle for many water non–soluble drugs when they are under investigations. During the conduct of a set of experiments, it was noted that ethanol on its own can induce some changes in function of skeletal nerve–muscle preparation. Therefore, in the present work, effect of different concentrations of ethanol (100, 200, 300 and 500mM) on the function of skeletal muscle was studied; in chick biventer cervices (CBC) nerve-muscle preparation using twitch tension record1ing technique. Twitches of the CBC were evoked by stimulating the motor nerve at 0.1 Hz with pulses of 0.2msec duration and a voltage of greater than that required to produce the maximum response. Twitches and contractures were recorded isotonically using Narco Biosystems. Results indicated that ethanol at concentrations of 100mM or higher can significantly increase the twitch height, so that, ethanol at concentration of 300mM did increase the twitch height to as much as a hundred percent. Concentrations of 300mM & higher did induce partial & occasionally total contracture. Therefore, it can be concluded that firstly, because of wide usage of ethanol as a solvent or vehicle, this effect of ethanol on skeletal muscle function must be taken into consideration; & secondly these finding are consistent with some literature reporting that ethanol produces a potentiation effect on the function of skeletal muscle, by an action of the drug on the motor nerve terminal.

 
Keyword(s): 
 
Yearly Visit 8   tarjomyar
 
Latest on Blog
Enter SID Blog