Paper Information

Title: 

MECHANISM OF INHIBITORY EFFECT OF FLUOXETINE ON ISOLATED GUINEA-PIG ATRIA IN RELATION TO ADENOSINE RECEPTOR

Type: SPEECH
Author(s): DIMYAD T.,BOROUMAND K.,MALIHI G.,POUSTI A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF TOXICOLOGY
Type of Seminar:  CONGRESS
Sponsor:  SOCIETY OF TOXICOLOGY
Date:  2004Volume 8
 
 
Abstract: 

The effect of fluoxetine (FL), a selective serotonin reuptake inhibitor antidepressant was studied on rate and force of contractions of isolated guinea-pig atria. FL (1-8g/ml) caused a dose-dependent decrease in the contractile force (41-53%) and in the rate of contractions (12-44%). These negative inotropic and chronotropic effect of FL (2g/ml) were not prevented by atropine (1g/ml) and 3,7 dimethyl-1-propargylxanthine (DMPX; 1g/ml) ,an adenosine A2 receptor antagonist , but 1,3 dipropargyl-8-cyclopentylxanthine (DPCPX; 12g/ml), a specific adenosine A1 receptor antagonist significantly blocked these effects (p<0.001) and theophylline (30g/ml) a non selective adenosine A1/A2A receptor antagonist has also prevented the inotropic and chronotropic effect of FL. These results suggest that the negative inotropic and chronotropic effect of FL on isolated guinea-pig atria is probably through an inhibition of the uptake of adenosine or the A1 receptor mechanism.

 
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