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Paper Information

Title: 

ALLELE DISTRIBUTION OF APOLIPOPROTEIN B (APO B) 3’ HYPER VARIABLE REGION POLYMORPHISM BETWEEN LURS AND SISTANI-VA-BALUCHI TWO ETHNIC GROUPS FROM IRAN

Type: PAPER
Author(s): MAHIANEH A.,BAYAT B.*,BANOUEI M.M.,SANATI M.M.,JAHANGIR SOLTANI N.,HASHEMZADEH M.*
 
 *SHAHR- E- KORD UNIVERSITY OF MEDICAL SCIENCE
 
Name of Seminar: NATIONAL CONGRESS OF BIOTECHNOLOGY OF IRAN
Type of Seminar:  CONGRESS
Sponsor:  IRANIAN BIOTECHNOLOGY ASSOCIATION
Date:  2005Volume 4
 
 
Abstract: 

The Apo B minisatellite as one of VNTR markers, located at chromosome2 (2p24), contain an AT-rich, 30bp core sequence, which has two structurally similar subunit with the repeat size ranging from 27 to 55. This marker has been extensively studied in global population throughout the world. It is reported Apo B gene and its hyper variable region polymorphism involve in wide rang of diseases specially neurodisorder like multiplesclorosis. 100 unrelated individuals were analyzed from two ethnic groups of Iran. Lur are population who settle mostly in west of Iran and they speak Luri which forms a dialect of Persian language, while they are ethnically close to the Kurds and Persians but especially resent being labeled as Kurdish, also other samples collected from ethnic group live in Souhteast of Iran from Sistan- va- Baluchestan province. They are belonging to Bulchi and Sistani ethnic, demographic manfestation show difference clearly between two selected groups.
We screened 200 chromosomes; DNA samples were extracted from whole blood, all fragments amplified by polymerase chain reaction and analyzed on polyacrylamide gel electrophoresis.
We found 23 and 19 alleles ranging from 30 to 55 with 36 and 28 genotype in Lurs and Sistani-Baluchi, respectively. Unpublished result about distribution of ApoB VNTR polymorphism among other ethnic groups in Iran including Fars, Azeri (Turk) and Kurd show similarities between Azeri, Kurd and Lur. Alleles 43 and 42 had high frequencies in Lur that Azeri and Kurd also show high frequency about same alleles. This was allele No. 43 and 40 for Sistani va Baluhi. Gst showed high level in these ethnic groups that derived from high genetic differentiation in mentioned groups.

 
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