Paper Information

Title: 

STUDY OF CYP2C9 CODON 144 POLYMORPHISM AMONG THREE ETHNIC GROUPS FROM IRAN

Type: PAPER
Author(s): BEYRAMI JAMAL F.*,TANHAEI S.,SANATI M.H.,SHEYDAEI MASOUD
 
 *NATIONAL INSTITUTE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY (NIGEB),TEHRAN, IRAN
 
Name of Seminar: NATIONAL CONGRESS OF BIOTECHNOLOGY OF IRAN
Type of Seminar:  CONGRESS
Sponsor:  IRANIAN BIOTECHNOLOGY ASSOCIATION
Date:  2005Volume 4
 
 
Abstract: 

CYP2C9 gene is one of xenobiotic metabolizing genes, especially drug-metabolizing. Enzyme activity of CYP2C9 have demonstrated to be reduced by two non synonymous SNP in this gene, which causes various response to some drugs and probably is a reason for different susceptibility to some cancer types. In this study we investigated the status of CYP2C9 codon 144 polymorphism in three different ethnic groups (Turkoman, Mazandarani, Kord) of Iran. Genotypes were determined by PCR-RFLP and direct DNA sequencing analysis in 121 healthy individual. Among the healthy subjects with Mazandarani, Turkaman and Kord ethnicity, the genotype frequency of CYP2C9 Cys144Arg were 16%, 9% and 14% for Cys allele, 84%, 91% and 86% for Arg allele. No significant difference in CYP2C9 allele distribution was observed between these groups. In each groups, the distribution of genotypes fits the Hardy-Weinberg equilibrium. This study can be a background for future studies like pharmacogenomic investigations and association studies.

 
Keyword(s): CYP2C9 GENE, NON SYNONYMOUS SNP, ENZYME ACTIVITY, ETHNIC GROUP
 
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