Paper Information

Title: 

INTERFERON RESISTANCE OF HEPATITIS C VIRUS GENOTYPES 1A/1B: RELATIONSHIP TO NONSTRUCTURAL 5A GENE QUASISPECIES MUTATIONS

Type: PAPER
Author(s): HASHEMPOUR T.,AMINI BAVIL OULIAEI S.,KARIMI M.,BEHZADIAN F.,RADMARD A.,SHAHZAMANI K.,HONAR DOUST M.,MERAT SH.,SABAHI F.
 
 
 
Name of Seminar: NATIONAL CONGRESS OF BIOTECHNOLOGY OF IRAN
Type of Seminar:  CONGRESS
Sponsor:  IRANIAN BIOTECHNOLOGY ASSOCIATION
Date:  2005Volume 4
 
 
Abstract: 

Recently, the Nonstructural 5A protein of hepatitis C virus (HCV) was reported to interact with double stranded RNA-dependent protein kinase (PKR) through PKR binding domain and its target, eukaryotic translation initiation factor (eIF) 2a. Inhibition of the kinase activity of PKR by this interaction was postulated as a mechanism for the resistance to interferon (IFN) therapy.
The aim of this study was to examine this issue in a series of patients with long-term response to IFN treatment.The patients were defined as long-term responders since they showed persisting biochemical and virological reaponse to IFN treatment.

 
Keyword(s): HEPATITIS C VIRUS, NONSTRUCTURAL 5A GENE, POLYMERASE CHAIN REACTION, INTERFERON
 
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