Paper Information

Title: 

IMPORTANCE OF IMMORTALIZED CELLS IN BIOBANKING

Type: PAPER
Author(s): ASADI MASOME*,MOHAMMADI SHIVA,IZADPANAH MEHRNAZ,SHAHZADE FAZELI ABOLHASSA,FARZANEH PARVANEH
 
 *IRANIAN BIORESOURCE CENTRE (IBRC)
 
Name of Seminar: CONGRESS OF IRANIAN GENETICS
Type of Seminar:  CONGRESS
Sponsor:  ZAKHAYERE ZHENETICE JAHADE DANESHGAHI
Date:  2014Volume 1
 
 
Abstract: 

BIOBANK IS A TYPE OF BIOREPOSITORY WHICH STORES HUMAN BIOLOGICAL SAMPLES FOR USE IN RESEARCH. BIOBANK HAS THREE MAIN OBJECTIVES THAT INCLUDE OF STORAGE OF FROZEN, STANDARD OF CARE AND RESEARCH APPLICATIONS. IN ORDER TO HAVE CONSISTENT MATERIAL THROUGHOUT A RESEARCH PROJECT, RESEARCHERS NEED PRIMARY CELLS WITH AN EXTENDED REPLICATIVE CAPACITY, OR IMMORTALIZED CELLS. SEVERAL METHODS EXIST FOR IMMORTALIZING MAMMALIAN CELLS IN CULTURE, INCLUDE TELOMERASE REVERSE TRANSCRIPTASE GENE OR VIRAL GENES. VIRAL GENES, INCLUDING EPSTEIN-BARR VIRUS, SIMIAN VIRUS 40 T ANTIGEN, ADENOVIRUS E1A AND E1B, AND HUMAN PAPILLOMAVIRUS E6 AND E7 INDUCE IMMORTALIZATION BY A PROCESS KNOWN AS VIRAL TRANSFORMATION. THUS IMMORTALIZED CELLS PROVIDE RESEARCH APPLICATIONS IN BIOBANKS.
NOW IRANIAN BIORESOURCE CENTRE (IBRC) IS A BIOBANK WICH ACTIVE IN IMMORTALIZATION CELLS AND STORE THE IMMORTALIZED SAMPLES.

 
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