Paper Information

Title: 

OPTIMIZATION OF THE MANUFACTURING PROCESS FOR BOVINE SERUM ALBUMIN (BSA) NANOPARTICLES

Type: PAPER
Author(s): AGHAJANI H.,SHOJA ALSADATI S.A.*,JAHANSHAHI M.
 
 *BIOTECHNOLOGY GROUP, CHEMICAL ENGINNERING DEPARTMENT, TARBIAT MODARRES UNIVERSITY, TEHRAN, I.R. IRAN
 
Name of Seminar: NATIONAL CONGRESS OF BIOTECHNOLOGY OF IRAN
Type of Seminar:  CONGRESS
Sponsor:  IRANIAN BIOTECHNOLOGY ASSOCIATION
Date:  2005Volume 4
 
 
Abstract: 

Nanoparticles prepared by desolvation and subsequent crosslinking of Bovine Serum Albumin (BSA) represent promising carriers for colloidal drug delivery systems. The produced nanoparticles were characterized with respect to size. The particles size is a crucial parameter, in particular for in vivo behavior of nanoparticles after injection. The present study aims at optimizing of the two parameters which can affect on the size of particles. Optimization of two parameters, protein concentration and rate of Ethanol addition was done by full factorial design. The screening presented that concentration has main effect on the mean size. Optimization of protein nanoparticles in the range of 5- 30 mg/ml of BSA was resulted 15 mg/ml has minimum mean size. AFM indicated the semispherical shape of particles.

 
Keyword(s): PROTEIN NANOPARTICLES, BOVINE SERUM ALBUMIN (BSA), PARTICLE SIZE DISTRIBUTION, DRUG DELIVERY
 
Yearly Visit 53   pdf-file tarjomyar
 
Latest on Blog
Enter SID Blog