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Paper Information

Title: 

EVALUATION OF PATHOGENICITY AND IMMUNOGENICITY OF NATIVE AND MUTANT STRAINS OF PASTEURELLA MULTOCIDA CAUSATIVE AGENTS OF HAEMORRHAGIC SEPTICAEMIA

Type: PAPER
Author(s):
 
 24-26 AUGUST, 2005
 
Name of Seminar: fldOnvanSeminar
Type of Seminar:  lblfldTypeSeminar
Sponsor:  IRANIAN BIOTECHNOLOGY ASSOCIATION
Date:  2005Volume 4
 
 
Abstract: 

Hemorrhagic septicemia (HS) is a fatal systemic disease of cattle and buffaloes. Some control is achieved with alum-precipitated or oil-adjuvanted killed whole-cell vaccines injected subcutaneously, but these vaccines provide only short-term immunity and require annual administration for effective use. We constructed an aroA attenuated derivative of a P. multocida serotype B:2 strain by allelic exchange of the native aroA sequence with aroA sequences disrupted with a kanamycin resistance cassette. This strain was confirmed to be aroA mutant by PCR. The aroA derivative was highly attenuated for virulence in a mouse model of HS and rabbits. Mouse and rabbit challenge experiments showed that i.p. or i.m. vaccination of an aroA strain completely protected mice or rabbits against challenge with a high dose (>1000 LD50) of the parent strain.

 
Keyword(s): P. MULTOCIDA, LIVE VACCINE, AROA MUTANT, HEMORRHAGIC SEPTICEMIA
 
 
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