Paper Information

Title: 

CASPASE INHIBITION AND NATURAL NEURON DEATH

Type: PAPER
Author(s): PARVANEH TAFRESHI A.*,ZEINALI B.
 
 *DEPARTMENT OF BIOCHEMISTRY, THE NATIONAL RESEARCH CENTRE FOR GENETIC ENGINERING AND BIOTECHNOLOGY, TEHRAN, 14155-6343
 
Name of Seminar: NATIONAL CONGRESS OF BIOTECHNOLOGY OF IRAN
Type of Seminar:  CONGRESS
Sponsor:  IRANIAN BIOTECHNOLOGY ASSOCIATION
Date:  2005Volume 4
 
 
Abstract: 

 Programmed cell death (PCD) during which up to 50% of the neurons die in a certain period of time, occurs in the developing nervous system. Proteases, among them caspases, are known to be involved in cell death. To investigate if any specific protease (s) has a key role in PCD, chicken embryos were treated daily from E6-E9 with different protease inhibitors in this study. Among the inhibitors available in market, those for the caspase inhibition in general and for the inhibition of caspase 8, caspase 9 and calpain were used. Embryos were killed at E10 and neurons were counted in cilliary ganglia (CG). As expected, there was a significant increase in neuron numbers in CGs of embryos treated with a general caspase inhibitor. Interestingly, among the other CGs, there was a significant increase in neuron numbers only in those treated with caspase 9 inhibitor. These results suggest a key role of caspase 9 in the intracellular pathway of PCD.

 
Keyword(s): PCD, CASPASE, CILLIARY GANGLIA, CHICK EMBRYOS
 
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