Paper Information

Title: 

FABRICATION OF A POROUS COMPOSITE SCAFFOLD BASED ON GELATIN AND HYDROXYAPATITE FOR BONE TISSUE ENGINEERING AND EVALUATION OF CELL ATTACHMENT

Type: PAPER
Author(s): ASKARZADEH TABRIZI KARIM,ORANG FARIBA,MOZTARZADEH FATHOLLAH
 
 
 
Name of Seminar: IRANIAN CONFERENCE ON BIOMEDICAL ENGINEERING
Type of Seminar:  CONFERENCE
Sponsor:  ANJOMANE MOHANDESI PEZESHKI IRAN
Date:  2004Volume 11
 
 
Abstract: 

GELATIN IS A PROTEIN DERIVED FROM THE ORGANIC CONSTITUENT OF BONE (COLLAGEN). COMBINATION OF THIS PROTEIN WITH THE INORGANIC CONSTITUENT (HYDROXYAPATITE) WOULD PROVIDE MUCH CLOSER PROPERTIES TO THE NATURAL BONE. THUS IN THIS STUDY A COMPOSITE SCAFFOLD BASED ON GELATIN AND HYDROXYAPATITE WAS OFFERED AS A BIODEGRADABLE SUBSTITUTE FOR BONE TISSUE. FABRICATION OF SUCH SCAFFOLDS WAS CARRIED OUT BY SOLVENT CASTING METHOD WITHOUT USING ANY ORGANIC SOLVENT INCREASING THE BIOCOMPATIBILITY LEVEL. POROSITIES OBTAINED HERE WERE QUITE SPONTANEOUS WITHOUT THE AID OF POROGENS. THE PORES INDICATED HIGH INTERCONNECTIVITIES WITH DIAMETERS RANGING FROM 50 TO 200 MICRONS, WHICH IS MUCH APPROPRIATE FOR BONE TISSUE ENGINEERING APPLICATIONS. IN ORDER TO STUDY THE BIOCOMPATIBILITY OF THE SCAFFOLDS, MOUSE FIBROBLASTIC CELLS WERE USED. AFTER 24-HOUR CELL CULTURE PERIOD, IN VITRO, SUITABLE CELL ATTACHMENT WAS OBSERVED SHOWING HIGH BIOCOMPATIBILITY FOR ALL THE SAMPLES. FURTHER EXAMINATIONS DEMONSTRATED THAT THE BEST BIOCOMPATIBILITY IS RELATED TO COMPOSITE OF 50 WT% HYDROXYAPATITE AND 50 WT% GELATIN.

 
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