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Paper Information

Title: 

SIMULATION OF BLOOD BRAIN BARRIER USING STATISTICAL METHOD

Type: PAPER
Author(s): YAHAGHI E.*,MOVAFEGHI A.,SOLTANIAN ZADEH H.,SHAHRIAREI M.,FATOURAEE N.,GITI -
 
 *DEPARTMENT OF PHYSICS, AMIRKABIR UNIVERSITY OF TECHNOLOGY
 
Name of Seminar: IRANIAN CONFERENCE ON BIOMEDICAL ENGINEERING
Type of Seminar:  CONFERENCE
Sponsor:  ANJOMANE MOHANDESI PEZESHKI IRAN
Date:  2004Volume 11
 
 
Abstract: 

WE DESCRIBE A NEW METHOD TO SIMULATE CROSSING OF CONTRAST AGENT ACCORDING TO PERMEABILITY AND LESIONS OF BLOOD BRAIN BARRIER. EQUATIONS OF TISSUE HOMOGENEITY MODEL (ADIABATIC EQUATIONS) AND COMPARTMENT MODEL ARE USED FOR DESCRIPTION OF DISTRIBUTION OF CONTRAST AGENT IN CAPILLARY AND EXTRAVASCULAR SPACE. ANALYTICAL METHODS FOR SOLVING ADIABATIC EQUATIONS WITH NON-UNIFORM PERMEABILITY AND REAL ARTERIAL INPUT FUNCTION (AIF) ARE COMPLICATED. WE CONSIDER CROSSING OF CONTRAST AGENT THROUGH THE CAPILLARY AND BBB AS INTRINSICALLY STATISTICAL PROCESSES. THEREFORE, IT IS SIMULATED BY A STOCHASTIC METHOD (MONTE CARLO METHOD). IN OUR MODEL, CAPILLARY IS DIVIDED INTO MULTIPLE SECTIONS AS IN PATLAK MODEL AND CONTRAST AGENT MOVES FROM ONE SECTION TO OTHER SECTIONS. FOR CAPILLARY INPUT, AIF IS USED DIRECTLY FROM REAL DATA. WITHOUT SOLVING ANY EQUATIONS, WE DERIVE THE CONCENTRATION OF CONTRAST AGENT AS A FUNCTION OF TIME AND DISTANCE IN THE CAPILLARY FOR NORMAL (NOT PERMEABLE DUE TO BBB) AND ABNORMAL CAPILLARY WITH UNIFORM AND NON-UNIFORM PERMEABILITY.

 
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