Paper Information

Title: 

THEORETICAL STUDY OF USING 2-PHENYLTHIALCOHOLS AS ANTIDOTE DRUGS, THE ROLE OF STEREOCHEMISTRY

Type: PAPER
Author(s): AMOUZADEH A.*,PEYVANDI P.
 
 *SEMNAN UNIVERSITY, DEPARTMENT OF CHEMISTRY
 
Name of Seminar: NATIONAL CONGRESS OF BIOTECHNOLOGY OF IRAN
Type of Seminar:  CONGRESS
Sponsor:  IRANIAN BIOTECHNOLOGY ASSOCIATION
Date:  2005Volume 4
 
 
Abstract: 

There are some commercial antidote drugs like Dimercaprol, Succimer, or Penicilamine as parmaceutical chelators. They are bidental ligands which could give strong complexes with heavy metals as poisons. This paper introduces 2-Phenylthioalcohols as theoretically new antidote drugs and describes the role of stereochemistry on their effect. The stability of mentioned ligands and their complexes with Zn2+ are calculated by semi-empirical AM1 method and compared together and to ordinary used antidote drugs. Also the simple synthetic methods have introduced for their preparation.

 
Keyword(s): ANTIDOTE, PHARMACEUTICAL CHELATORS, 2-PHENYLTHIOALCOHOLS, SEMI-EMPIRICAL AM1 METHOD
 
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