Paper Information

Title: 

PREVALENCE OF LATE SENSORINEURAL HEARING LOSS IN CHILDREN WITH HISTORY OF SEVERE HYPERBILLIRUBINEMIA

Type: PAPER
Author(s): LOTFI A.R.,ABDOLLAHI FAKHIM SHAHIN,MOHAMMADI GHAHHARI HAMED
 
 
 
Name of Seminar: INTERNATIONAL CONNGRESS OF IRANIAN SOCIETY OF OTOLARYNGYOLOGY / HEAD AND NECK SURGERY
Type of Seminar:  CONGRESS
Sponsor: 
Date:  2010Volume 1
 
 
Abstract: 

BACKGROUND AND OBJECTIVES: SEVERE HYPERBILLIRUBINEMIA IN THE NEONATAL PERIOD IS A RISK FACTOR FOR HEARING LOSS, AND ITS ROLE IS KNOWN AS A MAJOR RISK FACTOR FOR NEONATAL NON-SYNDROMIC AUDITORY NEUROPATHY. IN THIS STUDY, THE PREVALENCE OF HEARING LOSS IN TERM NEONATES WITH A HISTORY OF HYPERBILIRUBINEMIA WAS EVALUATED WITH ABR TEST AND THE RESULTS WERE COMPARED WITH THAT OF HEALTHY NEONATES.
METHODS AND MATERIALS: IN A COHORT STUDY, IN THE PEDIATRIC HOSPITAL OF TABRIZ, THE HEARING LOSS RATE IN 102 CHILDREN WHO HAD ONLY SEVERE NEONATAL HYPERBILIRUBINEMIA AS DEAFNESS RISK FACTOR WAS COMPARED WITH THAT OF 100 MATCHING HEALTHY NEONATES WITHOUT ANY KNOWN DEAFNESS RISK FACTORS. ALL SUBJECTS WERE EVALUATED WITH AUDITORY BRAIN STEM RESPONSE.
RESULTS: ALL NEONATES WERE FULL TERM. FIFTY-EIGHT OF THE CASE GROUP CHILDREN AND 61 OF THE CONTROL GROUP CHILDREN WERE BOYS AND 58 OF THE CASE GROUP CHILDREN AND 61 OF THE CONTROL GROUP CHILDREN WERE GIRLS (P=0.550). TWENTY-THREE NEONATES WITH HYPERBILIRUBINEMIA HAD AN ABNORMAL AUDITORY BRAIN STEM RESPONSE. SEVEN NEONATES OF THE CASE GROUP PATIENTS HAD MILD HEARING LOSS, EIGHT NEONATES OF THE CASE GROUP PATIENTS HAD MODERATE HEARING LOSS AND EIGHT NEONATES OF THE CASE GROUP PATIENTS HAD SEVERE HEARING LOSS. THE FREQUENCY OF ABNORMAL AUDITORY BRAIN STEM RESPONSE IN NEONATES WITH HYPERBILIRUBINEMIA WAS SIGNIFICANTLY HIGHER THAN THAT OF THE CONTROL GROUP NEONATES (P< 0.001).
CONCLUSION: THE MEAN OF BILIRUBIN IN THE CASE GROUP NEONATES WAS 35.30
± 5.02. SIX-POINT-NINE PERCENT OF THE CASE GROUP HAD MILD HEARING LOSS, %7.8 OF THE CASE GROUP HAD MODERATE HEARING LOSS AND %7.8 OF THE CASE GROUP HAD SEVERE HEARING LOSS. THE SEVERITY OF THE HEARING LOSS IN NEONATES WITH HYPERBILIRUBINEMIA WAS SIGNIFICANTLY HIGHER THAN THAT OF THE CONTROL GROUP NEONATES. TWENTY-TWO-POINT-FIVE PERCENT OF THE NEONATES WITH HYPERBILIRUBINEMIA HAD AN ABNORMAL AUDITORY BRAIN STEM RESPONSE WHICH WAS SIGNIFICANTLY HIGHER THAN THAT OF THE HEALTHY GROUP. IT IS RECOMMENDED TO EVALUATE THE HEARING STATE IN NEONATES WITH A HISTORY OF NEONATAL HYPERBILIRUBINEMIA WITH AUDITORY BRAIN STEM RESPONSE.

 
Keyword(s): HYPERBILLIRUBINEMIA, HEARING LOSS, AUDITORY BRAIN STEM RESPONSE, AUDITORY NEUROPATHY
 
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