Paper Information

Title:  ASSOCIATION BETWEEN P53 OVEREXPRESSION AND RECURRENCE IN LARYNGEAL SCC WITH NEGATIVE HISTOPATHOLOGIC MARGIN
Type: PAPER
Author(s): JALALI M.M.,JAMALI MANSOUR,HEIDARZADEH A.,SARMAST H.
 
 
 
Name of Seminar: INTERNATIONAL CONNGRESS OF IRANIAN SOCIETY OF OTOLARYNGYOLOGY / HEAD AND NECK SURGERY
Type of Seminar:  CONGRESS
Sponsor: 
Date:  2010Volume 1
 
 
Abstract: 

INTRODUCTION: THE MOST IMPORTANT PROGNOSTIC FACTOR FOR LARYNGEAL SCC IS THE TOTAL EXCISION OF NEOPLASM WITH SURGERY. THUS IF WE SEE NEOPLASTIC CELLS IN THE MICROSCOPIC ASSESSMENT OF MARGIN’S SPECIMEN, THE RECURRENCE RATE WILL BE SIGNIFICANTLY INCREASED AND THE SURVIVAL OF THE PATIENT WILL BE DECREASED. THUS WE DECIDED TO INVESTIGATE MUTANT P53 IN THE MARGIN OF SPECIMENS.
OBJECTIVE: ASSESSMENT OF ASSOCIATION BETWEEN P53 OVEREXPRESSION AND RECURRENCE IN LARYNGEAL SCC WITH NEGATIVE HISTOPATHOLOGIC MARGIN. MATERIALS AND METHODS: THIS STUDY WAS PERFORMED WITH A HISTORICAL COHORT METHOD ON THE PATIENTS WHO HAD UNDERGONE LARYNGECTOMY BECAUSE OF LARYNGEAL SCC. ACCORDING TO THE CENTRAL PATHOLOGY DEPARTMENT OF THE IMAM KHOMEINI HOSPITAL OF TEHRAN UNIVERSITY, THE SPECIMENS OF LARYNGEAL SCC THAT WERE EXCISED WITH LARYNGECTOMY FROM 1383 TO THE 1ST HALF OF 1387. AFTER HISTOPATHOLOGIC ASSESSMENT OF THE SPECIMENS’ MARGINS, THE SPECIMENS WITH POSITIVE MARGIN WERE EXCLUDED. IN THE NEGATIVE MARGINS, P53 ASSESSMENT AND PATIENTS’ FOLLOW-UP WERE PERFORMED. THE RECURRENCE RATE WAS DETERMINED, AND COMPARISON AND CONCLUSION WERE MADE.
RESULTS: AT THE END, 31 PATIENTS WITH NEGATIVEHISTOPATHOLOGIC MARGINS WERE DETERMINED TO HAVE THE CAPABILITY FOR FOLLOW-UP. IN THE ASSESSMENT OF P53 AT THE SPECIMENS’ MARGINS WITH THE I.H.C. METHOD, 26 PATIENTS HAD NEGATIVE MARGINS AND FIVE PATIENTS HAD POSITIVE MARGINS. IN THE FOLLOW UP OF PATIENTS WITH NEGATIVE MARGINS, ONLY FIVE CASES (19.2%) HAD RECURRENCE, WHEREAS IN THE PATIENTS WITH POSITIVE MARGINS, FOUR CASES (80%) HAD RECURRENCE. CONCLUSION: ACCORDING TO THE RISK RATIO ABOUT 4, MOLECULAR ANALYSIS IN THE SURGICAL MARGINS CAN HELP US TO DECIDE ABOUT MORE VIGOROUS ATTEMPTS, SUCH AS RADIATION, AFTER THE SURGERY.

 
Keyword(s): LARYNGEAL SCC, P53 GENE, RECURRENCE
 
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