Paper Information

Title: 

THE EFFECTS OF ALPRAZOLAM ON TINNITUS: A CROSSOVER RANDOMIZED CLINICAL TRIAL

Type: SPEECH
Author(s): JALALI M.M.*,KOUSHA A.A.K.,NAGHAVI S.E.,SOLEIMANI RODABEH
 
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Name of Seminar: INTERNATIONAL CONNGRESS OF IRANIAN SOCIETY OF OTOLARYNGYOLOGY / HEAD AND NECK SURGERY
Type of Seminar:  CONGRESS
Sponsor: 
Date:  2010Volume 1
 
 
Abstract: 

BACKGROUND: TINNITUS REMAINS A PHENOMENON WITH AN UNKNOWN PATHOPHYSIOLOGY FOR WHICH FEW THERAPEUTIC MEASURES ARE AVAILABLE. TO DATE, THERE HAS BEEN INSUFFICIENT EVIDENCE TO SUPPORT THE USE OF ALPRAZOLAM IN THE TREATMENT OF TINNITUS. WE SOUGHT TO EVALUATE THE EFFICACY OF ALPRAZOLAM FOR RELIEF OF TINNITUS.
MATERIAL AND METHODS: THIRTY-SIX TINNITUS SUFFERERS PARTICIPATED IN THIS CROSSOVER, RANDOMIZED, TRIPLE-BLIND, PLACEBO-CONTROLLED TRIAL. THE INCLUSION CRITERIA INCLUDED PATIENTS BEING BETWEEN 21 AND 65 YEARS OLD, AND A COMPLAINT OF NONPULSATILE TINNITUS OF MORE THAN ONE YEAR. PATIENTS WITH DEPRESSIVE OR ANXIETY DISORDERS WERE EXCLUDED, AS WERE THOSE USING HEARING AIDS. PARTICIPANTS RECEIVED 1.5 MG OF ALPRAZOLAM DAILY VERSUS PLACEBO IN THE CONTROL GROUP IN EACH PERIOD. PRIMARY OUTCOME VARIABLES INCLUDED THE TINNITUS HANDICAP INVENTORY (THI), A VISUAL ANALOG SCALE (VAS), AND THE TINNITUS LOUDNESS.
RESULTS: THIRTY PATIENTS COMPLETED THE STUDY. THE AVERAGE AGE OF THE PATIENTS WAS 47.58
±7.65 YEARS. ALPRAZOLAM IN COMPARISON WITH PLACEBO DID NOT RESULT IN STATISTICALLY SIGNIFICANTLY GREATER RELIEF IN THE THI SCORE AND TINNITUS LOUDNESS. THERE WAS A SIGNIFICANT IMPROVEMENT IN THE VAS SCORE IN THE ALPRAZOLAM GROUP COMPARED WITH THAT OF THE PLACEBO GROUP (P<0.001).
CONCLUSIONS: THESE RESULTS SUGGEST THAT ALTHOUGH ALPRAZOLAM DID NOT IMPROVE THE THI SCORE OR THE SENSATION LEVEL OF LOUDNESS SIGNIFICANTLY, IT HAD A DESIRABLE EFFECT ON THE VAS. FURTHER WORK IS NEEDED TO DETERMINE THE BENEFICIAL EFFECTS OF ALPRAZOLAM IN DISTRESSED OR DEPRESSED PATIENTS.

 
Keyword(s): TINNITUS, ALPRAZOLAM, CROSSOVER STUDIES
 
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