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Paper Information

Title: 

ASSOCIATION OF GLOBAL FIBRINOLYTIC CAPACITY WITH PROSTATE CARCINOMA

Type: PAPER
Author(s): MEHRABAN DARAB,NADERI GHOLAMHOSSEIN,TAFTACHI AHMAD REZA*,FADAKAR MAHMOUD,GULIYEV FUAD
 
 *
 
Name of Seminar: CONGREH ANJOMAN UROLOGY IRAN
Type of Seminar:  CONGRESS
Sponsor:  ANJOMAN OROLOGY
Date:  2005Volume 8
 
 
Abstract: 

PROPOSE: INCREASING OF FIBRINOLYSIS IN PROSTATE CARCINOMA IS WELL KNOWN. IT WAS REPORTED THAT PLASMA FIBRINOLYTIC CAPACITY IS A MEASURE OF FIBRINOLYSIS. GLOBAL FIBRINOLYTIC CAPACITY (GFC) WAS DESIGNED TO EVALUATE THE GLOBAL FIBRINOLYTIC POTENTIAL IN VITRO WITH A HIGH ACCURACY.
METHODS & MATERIALS: IN THIS STUDY, GFC WAS INVESTIGATED IN A GROUP OF PATIENTS (N=13) UNDERGONE RADICAL RETROPUBIC PROSTATECTOMY (RRP) FOR LOCALIZED PROSTATE CARCINOMA AND A GROUP OF PATIENTS (N=13) WITH LOCALLY INVASIVE OR METASTATIC DISEASE (MPC) BY COMPARING WITH A CONTROL GROUP (N=15) OPERATED FOR BENIGN PROSTATE HYPERPLASIA (BPH).
RESULTS: THERE WAS A FRANK DIFFERENCE IN GFC VALUES BETWEEN PREOPERATIVE VALUES OF BPH GROUP 1.29 (0.34-1.82) IN ONE SIDE AND PREOPERATIVE VALUES OF RRP 4.66 (2.46-8.35) AND MPC GROUPS 4.24 (0.2-7.45) ON THE OTHER HAND P=0.000 AND P=0.001 RESPECTIVELY. BUT THERE WAS NO SIGNIFICANT DIFFERENCE BETWEEN MPC AND PREOPERATIVE RRP GROUPS P=0762. THERE WAS A RISE IN GFC OF BPH GROUP ON POSTOPERATIVE 7TH DAY 2.17 (1.29-2.91) P=0.001 MEASUREMENTS IN CONTRAST TO A DROP OF THESE VALUES IN RRP GROUP 2.03 (0.26-3.16) P=0.001 WITH NO DIFFERENCE IN BETWEEN P=0.428.
DISCUSSION & CONCLUSION: GFC WAS FOUND TO BE SIGNIFICANTLY HIGHER IN PATIENTS WITH PROSTATE CANCER REGARDLESS OF THE STAGE AND DECREASED TO THE LEVEL OF BPH PATIENTS WHEN THE TUMOR WAS COMPLETELY REMOVED. THESE PRELIMINARY FINDINGS MAY HINT THAT GFC MAY BE USED AS A TUMOR MARKER FOR PROSTATE CANCER.

 
Keyword(s): FIBRINOLYSIS, GLOBAL FIBRINOLYTIC CAPACITY (GFC), PROSTATE CARCINOMA, TUMOR MARKER
 
 
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