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Paper Information

Title: 

THE EFFECT OF PENTOXIFYLLINE ON MOLITITY AND MORPHOLOGY OF SPERMATOZOA FROM EPIDIDYMAL AND RESTICULAR SAMPLES OF INFERTILES MEN

Type: PAPER
Author(s): VAHIDI S.*,KHALILI M.,SOFALI N.,HAIDARI A.M.
 
 *
 
Name of Seminar: CONGREH ANJOMAN UROLOGY IRAN
Type of Seminar:  CONGRESS
Sponsor:  ANJOMAN OROLOGY
Date:  2005Volume 8
 
 
Abstract: 

THERE ARE GENERALLY FACTORS INVOLVED IN MALE INFERTILITY: LOW COUNT, WEEK MOTILITY AND ABNORMAL MORPHOLOGY OF SPERMATOZOA. CURRENTLY, IT IS IMPOSSIBLE TO IMPROVE THE QUALITY OF SPERM COUNT AND MORPHOLOGY IN VIRTO. HOWEVER, IT MAY BECOME POSSIBLE TO IMPROVE THE SPERM MOTILITY BY ENHACER MEDICINE. THE OBJECTIVE WITH THE APPLICATION OF THIS STUDY WAS TO EVALATE THE EFFECT OF PENTOXIFYLINE (PX) ON SPERM MOTILITY AND MORPHOLOGY OF ASTHENOXOOSPERMIC EPIDIDYMAL AND TESRICULAR SAMPLES. THE SPECIMENS WERE RETRIEVED WITH PERCUTANEOUS EPIDIDYMAL SPERM ASPIRATION (PESA) AND TESTICULAR SPERM EXTRACTION (TESE) FROM MEN WITH OBSTRUCTIVE ZOOSPERMIA. A TOTAL OF 40 PESA AND 60 TESE SAMPLES WERE ALLOCATED TO THIS PROSPECTIVE STUDY. FOLLOWING PERLIMINARY EVALUATION EACH SAMPLE WAS PROCESSED WITH SWIM UP PROCEDURE AND THEN DIVIDED INTO TWO ALIQUOTS OF CONTROL (NON-PX) AND PX (3.5 PX). FOLLOWING 45 MIN OF INCUBATION AT 37C, THE PRECEVTAGE OF MOTILITY AND NORMAL MORPHOLOGY OF SPERMATOZOA WERE EVALUATED USING MACKLER CHAMBER AND PAPANICULAU STANING TECHNIQUE, RESPECTIVELY. THE MEAN SPERM COUNTS IN THE PESA AND TESE GROUP WERE 7.4±7.3´106 AND 2.43±1.3´106, RESPECTIVELY. THE PRECENTAGE OF NORMAL MORPHOLOGY IN THE ABOVE GROUP WERE 22.67±11.6 AND 14.9±9.2 WHICH.
WERE RESPECTIVELY CHANGED TO 23.2+15.7 AND 9.5+1.9 WITH PX INCUBATION. IN ADDITION, THE PRECENTAG OF CONTROL PEOGRESSIVE MOTILITY IN THE PESA AND TES SAMPLES WERE 13.9+4.2% AND 0.26+0.6% WHICH WERE INCREASED TO 20.2
±9.7% (P<0.001) AND 0.95±0.03% (P<0.05). THESE RESULT STRONGLY SUGGEST THAT PX WAS SUCCESFUL IN ENHANCING SPERM MOTILITY PARTICULARY IN THE PESA GROUP. IT ALSO DID NOT HAVE ANY SIG???? EFFECT ON SPERM MORPHOLOGY. PX IS CONCIDERED TO BE SAFE AND CHEAP, WITH EASY APPLICATION WHICH MAY BE USED FOR IMPROVING THE MALE INFERTILITY TREATMENT PROGRAM. WITH ITS DUAL ROLE AS MOTILITY ENHANCER AND VITALITY EDTECTOR OF SPERMATAZOA IT CAN BE USED SAFELY FOR THE ICSI TREATMENT OF SEVERE CASES OF ASTHENOZOOSPERMIA.

 
Keyword(s): INFERTILE MEN, PENTOXIFYLLINE, MOTILITY, MORPHOLOGY
 
 
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