Paper Information

Title: 

"IMPROVEMENT OF SPERM ACROSOME REACTION AFTER VARICOCELECTOMY: A PROSPECTIVE STUDY"

Type: PAPER
Author(s): AHMADI YADOLLAH*,ZOLFAGARI ALI,HOSEINZADEH -
 
 *
 
Name of Seminar: CONGREH ANJOMAN UROLOGY IRAN
Type of Seminar:  CONGRESS
Sponsor:  ANJOMAN OROLOGY
Date:  2005Volume 8
 
 
Abstract: 

PROPOSE: VARICOCELE IS A COMMON ETIOLOGY OF MALE INFERTILITY THAT CAUSES VARIOUS ABNORMALITIES IN SEMEN ANALYSIS. VARICOCELECTOMY IMPROVES ABOUT 70% OF THESE ABNORMALITIES. HOWEVER CONCEPTION RATE REMAIN ABOUT 40-50% AFTER VARICOCELECTOMY. THEREFORE IN RECENT DECADES STUDY OF SPERM FUNCTION IN PATIENTS WITH VARICOCELE HAS GOT IMPORTANCE. SPERM ACROSOME REACTION (AR) IS ONE OF THE IMPORTANT FUNCTIONS OF SPERM AND LAKE OF THIS FUNCTION SIGNIFICANTLY DECREASES CONCEPTION RATE OF SPERM METHODS & MATERIALS: IN THE PRESENT STUDY, SPERM AR WAS STUDIED BY TRIPLE STAINING TECHNIQUE IN PATIENTS WITH VARICOCELE. INITIALLY, TRIPLE STAINING TECHNIQUE WAS MODIFIED TO GOT BEST RESULTS. AS A CONTROL GROUP 20 FERTILE MEN ENROLLED IN THIS STUDY AND 38 PATIENTS WITH VARICOCELE UNDERWENT AS THE MAIN STUDY GROUP AND EVALUATED PROSPECTIVELY. THE LOWEST NORMAL AR IN CONTROL GROUP WAS 12%. THEREFORE AR LESS THAN THIS RANGE WERE ACCOUNTED ABNORMAL.
RESULTS: FOURTEEN OUT OF 38 PATIENTS (36.8%) HAD ABNORMAL AR BEFORE VARICOCELECTOMY. FIVE OF THESE 14 CASES (35.7%) WERE IMPROVED IN SIX MONTHS AFTER VARICOCELECTOMY (P<0.0002). HOWEVER, THREE MONTHS AFTER VARICOCELECTOMY AR WAS NOT AMELIORATED AND ALSO AR 2 OUT OF 38 PATIENTS WHO HAD NORMAL AR BECAME ABNORMAL. THERE WAS NO SIGNIFICANT RELATION BETWEEN VARICOCELE GRADING, CORRECTION OF MORPHOLOGY, MOTILITY AND CONCENTRATION OF SPERM WITH IMPROVEMENT OF AR AFTER SIX MONTHS VARICOCELECTOMY. IN ADDITION, IT WAS FOUND THAT AR IS AN INDEPENDENT VARIABLE FROM SEMEN ANALYSIS PARAMETERS.
DISCUSSION & CONCLUSION: ACCORDING TO THE CONCLUSION OF OUR STUDY; IN ALL PATIENTS WITH VARICOCELE, IT IS MANDATORY TO PERFORM AR BY MODIFIED TRIPLE STAINING TECHNIQUE AND VARICOCELECTOMY IS CARRIED OUT IN CASE OF ABNORMAL AR.

 
Keyword(s): ACROSOME REACTION, VARICOCELECTOMY, MODIFIED TRIPLE STAINING
 
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