Paper Information

Title: 

THE EFFECT OF GARLIC CYCLOSPORINE A INDUCED LDL CHANGES

Type: PAPER
Author(s): TAGHIZADEH AFSHARI A.,SHIRPOORA A.
 
 
 
Name of Seminar: CONGREH ANJOMAN UROLOGY IRAN
Type of Seminar:  CONGRESS
Sponsor:  ANJOMAN OROLOGY
Date:  2005Volume 8
 
 
Abstract: 

CYCLOSPORINE A IS A VERY POTENT IMMUNOSUPPRESSIVE DRUG WHICH IS USED TO PREVENT TRANSPLANT REJECTION. IN SPITE OF THIS BENEFICIAL EFFECT, THIS DRUG HAS DANGEROUS SIDE EFFECTS SUCH AS LDL RISE. THIS INCREASE IN LDL RESULTS IN CARDIOVASCULAR PROBLEMS IN SUBJECTS RECEIVING ALLOGRAFT TRANSPLANTATION. IN THIS STUDY THE EFFECT OF GARLIC ON CYCLOSPORINE INDUCED LDL RISE WAS INVESTIGATED. FORTY MALE WISTAR RATS WEIGHING 250 GR, AND WITH THE AGE OF 10 MONTHS WERE CHOSEN. THE RATS WERE GIVEN CYCLOSPORINE 25 MG/KG ORALLY FOR 30 DAYS. THEN BLOOD SAMPLING WAS DONE AND THEIR LDL LEVELS ASSAYED. RATS WITH LDL INCREASE WERE DIVIDED INTO TWO GROUPS OF EIGHT NAMELY CONTROL GROUP AND EXPERIMENTAL GROUP. EXPERIMENTAL RAPS RECEIVED GARLIC TABLET WITH THE DOSE OF 400 MG AND CYCLOSPORINE WITH THE SAME DOSE FOR 39 DAYS. CONTROL GROUP RECEIVED NORMAL DIET WITH CYCLOSPORINE. AT THE END OF EXPERIMENT, BLOOD SAMPLES WERE TAKEN SHOWED SIGNIFICANT INCREASE COMPARING TO THE PREVIOUS 30 DAYS (P<0.02). IN EXPERIMENTAL GROUP LDL LEVEL WAS DECREASED BUT IN FOUR RATS THIS DECREASE WAS MORE THAN 50% AND IT WAS SIGNIFICANT. THIS STUDY SHOWED THAT ALICINE (THE EFFECTIVE SUBSTANCE IN GARLIC) CAUSED LDL REDUCTION AND THIS REDUCTION CAN BE A USEFUL WAY FOR PATIENTS RECEIVING TRANSPLANT.

 
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