Paper Information

Title: 

"EFFECT OF SEX OF DONOR, BLOOD GROUP, AND AGE DIFFERENCE BETWEEN DONOR AND RECIPIENT ON EARLY ACUTE REJECTION IN 370 RENAL TRANSPLANTATION"

Type: PAPER
Author(s): MANSOORI DARYOUSH*,POURMAND GHOLAMREZA,MEHRSAI ABDOLRASOL,TAHERIMAHMOUDI MOHSEN
 
 *
 
Name of Seminar: CONGREH ANJOMAN UROLOGY IRAN
Type of Seminar:  CONGRESS
Sponsor:  ANJOMAN OROLOGY
Date:  2005Volume 8
 
 
Abstract: 

PROPOSE: OBJECTIVES: WE EXAMINED THE EFFECT OF SEX OF DONOR, BLOOD GROUP, AND AGE DIFFERENCE BETWEEN DONOR AND RECIPIENT IN A RETROSPECTIVE STUDY ON EPISODES OF EARLY ACUTE REJECTION.
METHODS & MATERIALS: MATERIALS: BETWEEN FEB 1996 TO SEP 2001, 370 RENAL TRANSPLANTATION DONE IN OUR CENTER. SEX OF DONOR, AGE OF DONOR AND RECIPIENT, BLOOD GROUP OF THE PATIENTS, AND EPISODE OF ACUTE REJECTION IN THE FIRST 60 DAYS AFTER TRANSPLANTATION WERE RECORDED IN AN ACCESS DATABASE FOR ANALYSIS. EPISODE OF REJECTION WAS PROVED BY COMBINATION OF RENAL BIOPSY, DOPPLER SONOGRAPHY AND RENAL SCAN. THE PATIENTS WITH COMPLETE DATA AVAILABLE ENROLLED IN THE STUDY. THE PAIRED-SAMPLES T-TEST WERE USED TO MEASURE LEVEL OF STATICALLY SIGNIFICANCE IN ALL ANALYSIS.
RESULTS: RESULTS: WE HAD 93 (25.1%) EPISODES OF ACUTE REJECTION IN 370 RENAL TRANSPLANTS. THE MEAN AGE DIFFERENCE BETWEEN DONOR AND RECIPIENT WAS 11.76+/- 9.60 YEARS IN REJECTION GROUP AND 14.00+/- 9.85 YEAR IN NON-REJECTION GROUP (P=0.070). REJECTION RATE WERE 27%, 26.2%, 24.3%, 7.1% RESPECTIVELY IN PATIENTS WITH BLOOD GROUP A, B, O, AND AB. THE BLOOD GROUPS HAD NO SIGNIFICANT EFFECT ON EARLY ACUTE REJECTION (P<0.05). WE HAD 48% RATE OF REJECTION IN FEMALE DONOR AND 31% RATE OF REJECTION IN MALE DONOR WHICH WAS NOT STATICALLY SIGNIFICANT (P<0.05) BUT RATE OF REJECTION WAS MORE IN GROUP WITH FEMALE SEX OF DONOR AND MALE OF RECIPIENT (34.8%).
DISCUSSION & CONCLUSION: CONCLUSIONS: ALTHOUGH BLOOD GROUP AND AGE DIFFERENCE BETWEEN DONOR AND RECIPIENT HAVE NO SIGNIFICANT EFFECT ON EARLY EPISODE OF ACUTE REJECTION AFTER RENAL TRANSPLANTATION, FEMALE SEX OF DONOR IS A RISK FACTOR.

 
Keyword(s): RENAL TRANSPLANT, AGE, SEX, REJECTION
 
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