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Paper Information

Title: 

THE EFFICACY OF INTRAVESICAL BACILLUS CALMETTE-GUERIN IN THE TREATMENT OF FEMALE PATIENT WITH INTERSTITIAL CYSTITIS. A DOUBLE-BLIND, PROSPECTIVE, PLACEBO CONTROLLED TRIAL

Type: PAPER
Author(s): HEIDARI M.*,IRANI DARYOUSH,KHEZRI A.A.
 
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Name of Seminar: CONGREH ANJOMAN UROLOGY IRAN
Type of Seminar:  CONGRESS
Sponsor:  ANJOMAN OROLOGY
Date:  2005Volume 8
 
 
Abstract: 

PURPOSE: WE EVALUATED SAFETY AND EFFICACY OF INTRAVESICAL BACILLUS CALMETTE-GUERIN IN THE TREATMENT OF FEMALE PATIENTS WITH INTERESTITIAL CYSTITIS, IN A DOUBLE-BLIND, PROSPECIVE, PALCEBO CONTROLLED STUDY.
MATERIALS AND METHODS: 30 WOMEN MEETING THE NATIONAL INSTITUTE OF ARTHRITIS, DIABETES, DIGESTIVE AND KIDNEY DISEASES CRITERIA FOR INTERSTITIAL CYSTITIS, RANDOMIZED IN DOUBLE-BLIND FASHION IN TWO GROUP EACH CONSISTED OF 15 PATIENTS TO RECIEVE SIX, WEEKLY INSTILLATION OF 120 MG BCG VACCINE OF IRANIAN INSTITUTE OF PASTOR OR PLACEBO.
PERIODIC QUESTIONNAIRES ON SYMPTOMS OF INTERSTITIAL CYSTITIS, VOIDING DIARIES, BLADDER CAPACITY AT FIRST DESIRE TO VOID AND MAXIMUM BLADDER CAPACITY WERE OBTAINED. ADVERSE EVENTS WERE CLOSELY MONITORED DURING TREATMENT AND FOLLOW UP PHASES OF STUDY.
SUBJECTIVE AND OBJECTIVE BASELINE VALUES WERE COMPARED TO FOLLOW UP DATAS.
RESULTS: WITH MEAN FOLLOW UP OF 24 MONTHS (RANGE 6-33 MO) DEMONSTRATED 11 OF 15 (73%) BCG RESPONSE RATE, COMPARED TO 3 OF 15 (20%) PLACEBO RESPONSE RATE. RESPONDERS WERE DEFINED THE PATIENTS WITH MORE THAN 40% IMPROVEMENT IN THE SYMPTOMS OF INTERSTITIAL CYSTITIS. THE GLOBAL IMPROVEMENT IN SIGNS AND SYMPTOMS OF INTERSTITIAL CYSTITIS WAS 62%. ADVERSE EVENTS WERE SIMILAR IN BOTH GROUP, MOSTLY IRRITATIVE IN NATURE AND NO SIGNIFICANT SYSTEMIC EVEN WAS NOTED. BCG DOES NOT WORSEN INTERSTITIAL CYSTITIS SYMPTOMS.
CONCLUSION: WE CONCLUDED THAT INTRAVESICAL BCG IS SAFE, EFFECTIVE, AVAILABLE AND UNEXPENSIVE WITH RELATIVELY DURABLE RESULTS IN THE TREATMENT OF INTERSTITIAL CYSTITIS.

 
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