Paper Information

Title:  STUDY AND COMPARISON OF HYPOCITRATURIA AND HYPEROXALURIA IN PATIENTS WITH RECURRENT RENAL CALCULI AND CONTROL GROUP
Type: PAPER
Author(s): MAZDAK HAMID*
 
 *ESFAHAN MEDICAL SCHOOL
 
Name of Seminar: CONGREH ANJOMAN UROLOGY IRAN
Type of Seminar:  CONGRESS
Sponsor:  ANJOMAN OROLOGY
Date:  2005Volume 8
 
 
Abstract: 

RENAL CALCULI ON WHICH A FORTUNE IS DISBURSED IN THE SOCIETY IS A PREVALENT DISORDER. THERE ARE A NUMBER OF INHIBITORS AND PRECIPITATORS CAUSING RENAL CALCULI IN WHICH CITRATE IS THE MOST IMPORTANT INHIBITOR AND OXALATE IS THE MOST IMPORTANT PRECIPITATOR. SICNE NO ISOLATED STUDIES HAVE BEEN ABOUT THE PREVALENCE OF HYPOCITRATURIA AND HYPEROXALURIA IN PATIENTS WITH RECURRENT RENAL CALCULI COMPARING WITH CONTROL GROUP IN IRAN AND SPECIALLY ESFAHAN, IT SEEMED TO BE NECESSARY TO HAVE A STUDY IN THIS FIELD IN ORDER TO MEASURE THE LEVEL OF OXALATE AND CITRATE IN 240HR URINE AS A DIAGNOSIC AND CURATIVE PROTOCOL IF THERE WERE A SIGNIFICANT DIFFERENCE.
PURPOSE: THE PURPOSE OF THE STUDY WAS DETERMINING THE LEVEL OF OXALATE AND CITRATE IN 24-HR URINE OF PATIENTS WITH RECURRENT RENAL CALCULI AND CONTROL GROUP.
METHODS AND MATERIALS: THIS IS A PROSPECTIVE CASE CONTROL STUDY IN WHICH THE LEVEL OF CITRATE AND OXALATE IN 24-HR URINE IN 65 PATIENTS WITH RECURRENT RENAL CACULI WAS MEASURED AND COMPARIED WITH THE LEVEL OF 35 SAMPLE OF THE CONTROL GROUP CHOSEN RANDOMLY IN THE SOCIETY. THE ANALYSIS OF DATA WAS DONE WITH SPSS SOFT WARE AND TEST AND CHI-SQUARE.
RESULT: HYPOCITRATURIA WAS FOUND IN 57.1% OF THE CONTROL GROUP AND 50.80% OF CASE GROUP. (PV= 0.542) THE AVERAGE AGE OF CONTROL GROUP WHO HAD HYPOCITRATURIA WAS 38.911.8 WHEREAS IT WAS 41.816.7 IN OTHER PEPOLE WITH NORMAL LEVEL OF CIRTRATE IN CONTROL GROUP. THERE WASN’T MEANINGFUL RELATIONSHIP IN CASE GROUP. (PV=0.505) NO RELATIONSHIP WAS FOUND BETWEEN THE AGE AND HYPOCITRATURIA IN THE CASE GROUP. (PV 0.000L) THE AVERAGE OXALATE LEVEL IN 24-HR URINE WAS 16 MG IN CONTROL GROUP AND 41 MG IN CASE GROUP (PV 0.05) THERE WAS NOT A RELATIONSHIP BETWEEN GENDER AND HYPEROXALURIA IN CONTROL GROUP BUT IN CASE GROUP, HYPER OXALURIA WAS MORE PREVALENT IN MALES (47.8% IN MALES AND 21.1% IN FEMALES WITH PV 0.05). THERE WASN’T A RELATIONSHIP BETWEEN HYPEROXALURIA AND AGE IN BOTH GROUP (PV 0.05).
DISCUSSION: IN THIS SUDY NO RELATIONSHIP WAS FOUND BETWEEN HYPOCITRATURIA. RECURRENT RENAL CALCULI AND AGE OR GENDER; AS WELL ON THE CONTRARY, HYPEROXALURIA WAS SIGNIFICANTLY MORE PREVLENT IN PATIENTS WITH RECURRENT RENAL CALCULI THAN HEALTHY PEPOLE. HYPEROXALURIA WAS NOT RELATED WITH AGE IN BOTH GROUP. THERE WAS NO RELATIONSHIP BETWEEN HYPEROXALURIA AND AGE IN CONTROL GROUP BUT IN CASE GROUP, HYPEROXALURI WAS MORE PREVALENT IN MALES.
HENCE CONSIDERING THE LOW UNMBER OF CASES BEING INVOLVED IN THIS STUDY MORE CASES SHOULD BE STUDIES.

 
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