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Paper Information

Title: 

COMPARISON OF THE EFFICACY OF FIUOXETINE ALONE VS. FIUOXETINE PLUS EMLA CREAM IN THE TREATMENT OF PREMATURE EJACULATION

Type: PAPER
Author(s): AGHAMIR S.M.K.*,HOSSEINI S.R.
 
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Name of Seminar: CONGREH ANJOMAN UROLOGY IRAN
Type of Seminar:  CONGRESS
Sponsor:  ANJOMAN OROLOGY
Date:  2005Volume 8
 
 
Abstract: 

PROPOSE: BEHAVIORAL THERAPY IS CONSIDERED THE GOLD STANDARD FOR THE TREATMENT OF PREMATURE EJACULATION (P. E). MOST PATIENTS WHO NOTED IMPROVEMENT IN EJACULATORY LATENCY WITH THESE TREATMENTS FAIL TO MAINTAIN THE GAINS FOR THE LONG TERM. ORAL PHARMACOTHERAPY USING TRICYCLIC ANTI DEPRESSANTS (CLOMIPRAMINE) OR SELECTION SEROTONIN-REUPTAKE INHIBITOR DRUGS (FLUOXTINE) HAVE BEEN USED AS ALTERNATIVE TO BEHAVIORAL THERAPY. THE PRESENT STUDY EVALUATES THE EFFICACY FLUOXETINE PLUS EMLA CREAM IN THE TREATMENT OF P. E.
METHODS & MATERIALS: BETWEEN DECEMBER 2001 AND SEPTEMBER 2002, 38 MEN WITH P. E. (INTRAVAGINAL EJACULATION LATENCY OF LESS THAN 2 MINUTES) WERE STUDIED, PROSPETIVELY. THE EXCLUSION CRITERIA WERE ERECTILE DYSFUNCTION, PROSTATITIS, URETHRITIS, DIABETES MELLITUS, LOSS OF LIBIDO AND ALCOHOL AND CIGARETTE SMOKING. PATIENTS TOOK FLUOXETINE (20 MG DAILY) FOR A 4 WEEK PERIOD WITH A WASHOUT PERIOD OF 1 WEEK BETWEEN AGENTS. AFTER THAT PATIENTS TOOK FLUOXETINE PLUS EMLA CREAM FOR A 4 WEEK PERIOD. EJACULATION LATENCY WAS SUBJECTIVE. T TEST WAS USED FOR EJACULATION LATENCY BEFORE AND AFTER TREATMENT. THE CHI-SQUARE TEST WAS USED FOR SATISFACTION OF PATIENTS BEFORE AND AFTER TREATMENT.
RESULTS: : 38 MEN WITH MEAN AGE OF 35 YEARS (25-60) WERE STUDIED. AFTER 4 WEEKS TREATMENT WITH FLUOXETINE AND FLUOXETINE PLUS EMLA CREAM, EJACULATION LATENCY INCREASED FROM 45±40 SECONDS TO 3.20±2.18 MINUTES AND 6.30±5.50 MINUTES, RESPECTIVELY (P<0.01). EJACULATION LATENCY AFTER TREATMENT WITH FLUOXETINE PLUS EMLA CREAM WAS SIGNIFICANTLY HIGHER THAN FLUOXETINE ALONE. EFFICACY OF FLUOXETINE AND FLUOXETINE PLUS EMLA CREAM (PROLONGATION OF INTRAVAGINAL EJACULATION LATENCY) WERE 78% AND 48%, RESPECTIVELY. PATIENTS SEXUAL SATISFACTION AFTER TREATMENT OF COMBINANT THERAPY AND FLUOXETINE ALONE WERE 68% AND 41%, RESPECTIVELY. DIEFFERENCES BETWEEN THESE DRUGS WERE STATISTICALLY SIGNIFICANT (P<0.05). THERE WERE NO STATISTICAL DIFFERENCES BETWEEN THEM ACCORDING TO THE SIDE EFFECTS (P 0/01).
CONCLUSION: THE COMBINATION OF FLUOXETINE PLUS EMLA CREAM WAS FOUND TO BE MORE EFFECTIVE THAN FLUOXETIN ALONE IN THE TREATMENT OF P. E. HOWEVER, THE RESULTS SHOULD BE CONFIRMED IN FURTHER STUDIES WITH A PLACEBO GROUP TO RULE OUT THE PLACEBO EFFECT.

 
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