Paper Information

Title: 

ENDOSCOPIC TREATMENT OF VESICOURETERAL REFLUX (VUR) WITH A NEW DOMESTIC BIOCOMPATIBLE MATERIAL IN THE DOG

Type: PAPER
Author(s): MARJANI M.*,KAJBAFZADEH A.M.,BAKHTIARI J.
 
 *
 
Name of Seminar: CONGREH ANJOMAN UROLOGY IRAN
Type of Seminar:  CONGRESS
Sponsor:  ANJOMAN OROLOGY
Date:  2005Volume 8
 
 
Abstract: 

OBJECTIVES: VARIOUS PHARMACOLOGIC OR SURGICAL METHODS ARE USED IN THE TREATMENT OF VESICOURETERAL REFLUX (VUR), THE NEWEST OF WHICH IS SUBURETERIC INJECTION OF BIOCOMPATIBLE MATERIALS AT THE URETEROVESICAL JUNCTION (UVJ). BECAUSE NEW BIOCOMPATIBLE MATERIALS ARE NOT TESTABLE ON HUMAN IN THE FIRST RUN AND MIGHT CAUSE UNWANTED EFFECTS OR ALLERGIC REACTIONS, THE CURRENT STUDY HAS BEEN DESIGNED TO TEST SUCH MATERIALS IN THE DOG MODEL. DESIRED RESULTS WERE CONCLUDED FOLLOWING COMPARISON WITH THE COMMONLY USED MATERIAL, UROCHOL.
METHODS: NINE DOGS WITH BILATERAL VESICOURETERAL REFLUX WERE DIVIDED INTO THREE GROUPS OF THREE. IN THE FIRST GROUP, ONE WEEK AFTER CYSTOGRAPHIC CONFIRMATION OF REFLUX, THE NEW MATERIAL WAS INJECTED IN ONE SIDE AND UROCHOL IN THE OTHER. IN THE SECOND GROUP, THE SAME PROCEDURE WAS REPEATED WITH THE NEW MATERIAL FOR ONE SIDE AND DISTILLED WATER FOR THE OTHER. IN THE THIRD GROUP, UROCHOL WAS INJECTED IN ONE SIDE AND DISTILLED WATER IN THE OTHER, FOR COMPARISON. BECAUSE THE MAIN PURPOSE WAS TO COMPARE THE THERAPEUTIC COURSE OF THE NEW MATERIAL WITH THE ROUTINE ONE, REPEAT CYSTOGRAPHY WAS PERFORMED ONE WEEK AFTER THE ABOVE PROCEDURES.
RESULTS AND CONCLUSION: ACCORDING TO THE RESULTS IN ALL THE 9 REFLUXING DOGS, IT IS CONCLUDED THAT THE NEW MATERIALS HAVE EFFECTS SIMILAR TO THE COMMON DRUGS ALREADY IN USE. IN THE CURRENT INVESTIGATION, THE AMOUNT OF DRUGS INJECTED, INJECTION METHOD, ANATOMICAL FINDINGS AFTER THERAPY, AND DETAILS OF THE WORK HAVE BEEN RECORDED, AIMED AT SERVING AS A PROPER GUIDE FOR FUTURE USE BY OTHER INVESTIGATORS IN THE FIELD.

 
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