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Paper Information

Title: 

DNA PLOIDY IN WILMS TUMOR IN IRAN

Type: PAPER
Author(s): PASHM FOROUSH A.H.*,KAJBAFZADEH A.M.,PEDRAM M.,SOTOUDEH M.
 
 *
 
Name of Seminar: CONGREH ANJOMAN UROLOGY IRAN
Type of Seminar:  CONGRESS
Sponsor:  ANJOMAN OROLOGY
Date:  2005Volume 8
 
 
Abstract: 

OBJECTIVES: TO EVALUATE THE DNA POLIDY ON IMAGE CYTOMETRY IN CHILDREN WITH WILMS TUMOR AND CORRELATE WITH THE LONG TERM FOLLOW-UP. TO CORRELATE THE HISTOLOGIC FINDINGS WITH DNA IMAGE CYTOMETRY IN WILM’S TUMOR.
PATIENTS AND METHODS: FROM 1987-1987, FORTY-ONE CHILDREN WITH WILM’S TUMOR WERE OPERATED AT OUR UNIT WITH COMPLETE FOLLOW-UP BETWEEN 12-124MONTHS (AVERAGE; 61 MONTHS). THE MEAN AGE AT PRESENTATION WAS 3.5 YEARS (BETWEEN 6 MONTHS TO 9 YEARS). FROM THESE 26 WERE MALES AND 15 WERE FEMALES. TUMOR HISTOLOGY WERE REPORTED AS FAVORABLE (FH) (N=21) AND UNFAVORABLE (UFH) (N=20). TUMOR STAGING: STAGE I (N=6), STAGE II (N=12), STAGE III (N=16), STAGE IV (N=6), STAGE V (N=1).
RESULTS: TUMOR RECURRENCE WAS OBSERVED IN 9 PATIENTS (21.9%) IN DUE COURSE (ONE TUMOR RECURRENCE IN CHILDREN WITH FH AND 8 RECURRENCES IN PATIENTS WITH UFH. ALL RECURRENCESES WERE OCCUR IN CHILDREN WITH ANAPLOID DNA EITHER WITH FH (N=1) OR WITH UNFH (N=8) HISTOLOGY.
HISTOLOGIC FINDINGS AND DNA IMAGE CYTOMETRY IN 41 CASES (%):

HISTOLOGY                   DIPLOID     TETRAPLOID    ANAPLOID    TOTAL

FAVORABLE HISTOLOGY      67%            0                 33%        100%

UNFAVORABLE HISTOLOGY 27.5%         10%          62.5%        100%


CORRELATION BETWEEN HISTOLOGIC FINDINGS AND 1-5 YEARS SURVIVAL

HISTOLOGY  1  Y SURVIVAL  2 Y. SURVIVAL 3Y. SURVIVAL  4 Y SURVIVAL 5 Y SURVIVAL

FAVORABLE HISTOLOGY 100%         95%            95%          95%                95%              

UNFAVORABLE HISTOLOGY   91%     80%           77%           77%                77%


CORRELATION BETWEEN DNA ANALYSIS AND 1-5 YEARS SURVIVAL

IMAGE CYTOMETRY   1 Y SURVIVAL    2 Y. SURVIVAL   5 Y SURVIVAL

DIPLOID                      100%             100%              100%                   

ANAPLOID                    91%                82%                63%                   

OBJECTIVES: TO EVALUATE THE DNA POLIDY ON IMAGE CYTOMETRY IN CHILDREN WITH WILMS TUMOR AND CORRELATE WITH THE LONG TERM FOLLOW-UP. TO CORRELATE THE HISTOLOGIC FINDINGS WITH DNA IMAGE CYTOMETRY IN WILM’S TUMOR.
PATIENTS AND METHODS: FROM 1987-1987, FORTY-ONE CHILDREN WITH WILM’S TUMOR WERE OPERATED AT OUR UNIT WITH COMPLETE FOLLOW-UP BETWEEN 12-124MONTHS (AVERAGE; 61 MONTHS). THE MEAN AGE AT PRESENTATION WAS 3.5 YEARS (BETWEEN 6 MONTHS TO 9 YEARS). FROM THESE 26 WERE MALES AND 15 WERE FEMALES. TUMOR HISTOLOGY WERE REPORTED AS FAVORABLE (FH) (N=21) AND UNFAVORABLE (UFH) (N=20). TUMOR STAGING: STAGE I (N=6), STAGE II (N=12), STAGE III (N=16), STAGE IV (N=6), STAGE V (N=1).
RESULTS: TUMOR RECURRENCE WAS OBSERVED IN 9 PATIENTS (21.9%) IN DUE COURSE (ONE TUMOR RECURRENCE IN CHILDREN WITH FH AND 8 RECURRENCES IN PATIENTS WITH UFH. ALL RECURRENCESES WERE OCCUR IN CHILDREN WITH ANAPLOID DNA EITHER WITH FH (N=1) OR WITH UNFH (N=8) HISTOLOGY.
HISTOLOGIC FINDINGS AND DNA IMAGE CYTOMETRY IN 41 CASES (%):

HISTOLOGY                   DIPLOID     TETRAPLOID    ANAPLOID    TOTAL

FAVORABLE HISTOLOGY      67%            0                 33%        100%

UNFAVORABLE HISTOLOGY 27.5%         10%          62.5%        100%


CORRELATION BETWEEN HISTOLOGIC FINDINGS AND 1-5 YEARS SURVIVAL

HISTOLOGY  1  Y SURVIVAL  2 Y. SURVIVAL 3Y. SURVIVAL  4 Y SURVIVAL 5 Y SURVIVAL

FAVORABLE HISTOLOGY 100%         95%            95%          95%                95%              

UNFAVORABLE HISTOLOGY   91%     80%           77%           77%                77%


CORRELATION BETWEEN DNA ANALYSIS AND 1-5 YEARS SURVIVAL

IMAGE CYTOMETRY   1 Y SURVIVAL    2 Y. SURVIVAL   5 Y SURVIVAL

DIPLOID                      100%             100%              100%                   

ANAPLOID                    91%                82%                63%                   


CONCLUSION: IN CONCLUSION CORRELATION BETWEEN HISTOLOGIC FINDINGS (FH VE. UNFH) AND PATIENTS SURVIVAL AS WELL AS POST CHEMOTHERAPY TUMOR RECURRENCE RATE ARE WELL DOCUMENTED. THE COMBINATION OF IMAGE CYTOMETRY AND HISTOLOGIC FINDINGS MAY CORRELATE IN DETECTION OF HIGH RISK PATIENT AS WELL AS TO PREDICT THE PATIENTS SURVIVAL AND TUMOR RECURRENCE IN WILM’S TUMOR.

 
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