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Paper Information

Title: 

MOLECULAR FARMING,THE THIRD WAVES OF AGRICULTURAL BIOTECHNOLOGY

Type: PAPER
Author(s): MODANLOU KORDI SAJAD,GHAFARI MANSOUR
 
 
 
Name of Seminar: HAMAYESHE MANTAGHEI KARBORD FANAVARIHAYE NOVIN DAR KESHAVARZI
Type of Seminar:  CONGRESS
Sponsor:  Islamic Azad University, Shiraz
Date:  2008Volume 1
 
 
Abstract: 

MOLECULAR FARMING INVOLVES THE PRODUCTION OF NOVEL, USUALLY NON-PLANT PRODUCTS IN GENETICALLY MODIFIED PLANTS. BIOPHARMING REFERS TO THE PRODUCTION OF PLANT-MADE PHARMACEUTICALS (PMPS) BY CONSTRUCTING TRANSGENIC PLANTS THAT CAN CHEAPLY PRODUCE PHARMACEUTICAL PROTEINS (E.G. VACCINES). THE PROTEINS CAN THEN BE HARVESTED AND USED TO PRODUCE PHARMACEUTICALS. PLANT SYSTEMS PROVIDE SEVERAL KEY ADVANTAGES TO ANIMAL-CELL-BASED SYSTEMS FOR THE EXPRESSION OF RECOMBINANT PROTEINS. FIRST, ANIMAL PATHOGENS ARE ABSENT, AND THEREFORE OF NO SAFETY CONCERN. SECONDLY, THE YIELD OF PROTEIN PER WET TISSUE WEIGHT CAN BE ANY TIMES LARGER THAN THAT OBTAINED IN ANIMAL-CELL-BASED SYSTEMS. FINALLY, PLANT SYSTEMS CAN PERFORM MOST OF THE POST-TRANSLATIONAL AND CO-TRANSLATIONAL MODIFICATIONS OBSERVED WITH ANIMAL-CELL SYSTEMS. FOURTHLY, AND POSSIBLY MOST IMPORTANTLY IN THE CONTEXT OF THE PRESENT PROPOSAL, PLANT SYSTEMS HAVE THE POTENTIAL TO BE FAR CHEAPER PLATFORMS FOR THE PRODUCTION OF MEDICINAL PROTEINS. FINALLY, AND POSSIBLY MOST IMPORTANTLY, PLANT SYSTEMS HAVE THE POTENTIAL TO BE FAR CHEAPER PLATFORMS FOR THE PRODUCTION OF MEDICINAL PROTEINS. RECOMBINANT PROTEIN DRUGS ARE ONE OF THE FASTEST GROWING SEGMENTS OF THE PHARMACEUTICAL INDUSTRY GENERATING $20 BILLION IN ANNUAL REVENUES.

 
Keyword(s): MOLECULAR FARMING, AGRICULTURAL BIOTECHNOLOGY, TRANSGENIC PLANTS, PROTEIN
 
 
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