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Paper Information

Title: 

EFFECTS OF ISCHEMIA-REPERFUSION ON RAT RENAL TISSUE ANTIOXIDANT SYSTEMS AND LIPID PEROXIDATION

Type: POSTER
Author(s): RASOULIAN B.,VAHAB AGHAEI H.*,JAFARI M.,ASGARI A.R.,KHOUSHBATEN A.
 
 *RESEARCH CENTER FOR TRAUMA, BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Renal ischemia-reperfusion (IR) injury is a relatively common clinical problem. Endogenous antioxidants seem to have an important role in decreasing renal IR injury. The aim of this study was to investigate the effects of kidney IR on some renal antioxidant systems and lipid peroxidation
 Methods: About 20 male Wister rats (200-280gr) were divided to two groups and after right nephrectomy, the left renal artery was clamped for 40min in IR group. In control group ischemia was not induced. 24h postoperatively, serum and kidney tissue samples were obtained. Renal catalase and superoxide dismutase (SOD) activities and renal glutathione (GSH) and malondialdehyde (MDA, an end product of lipid peroxidation) levels were quantified.
Results: Renal IR increased serum creatinine and urea level [90.59±12.93 vs. 44.06±4.07 µmol/L, (p<0.01) and 40.22±10.27 vs. 20.8±1.8 mmol/L, (p<0.05), respectively]. Catalase activity was lower (33.13±2.02 vs. 43.78±2.38 units/mg protein, p<0.01) but SOD activity was higher (57.59±4.64 vs. 42.84±1.85 units/mg protein, p<0.05) in IR than control group. The GSH level also was lower (24.67±2.31 vs. 37.44±3.09 nmol/mg protein p<0.01) in IR group. MDA level was not significantly different between two groups (2.05±0.27 vs. 1.84±0.2 nmol/mg protein).
Conclusion: Our data indicated that despite decrease in renal GSH level and catalase activity following IR, SOD activity was increased.

 
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