Paper Information

Title: 

DETERMINATION OF AFFECTING FACTORS IN LIPID PEROXIDATION OF HEMODIALYSIS AND RENAL TRANSPLANTED PATIENTS

Type: POSTER
Author(s): MOSHTAGHI KASHANIAN GH.R.*,RASHTCHIZADEH N.,ARDAKANI H.,GHORBANI HAGHJOU A.
 
 *PHYSIOLOGY RESEARCH CENTER, KERMAN UNIVERSITY OF MEDICAL SCIENCE
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Arteriosclerosis is the most important cause of death in hemodialysis and renal transplanted patients while hyperlipidemia and lipid peroxidation are major risk factors of it. Since peroxidation of lipids are a multifactorial process, we investigate, serum lipid profile, albumin, total magnesium, malondialdehyde (MDA) and total antioxidant of 30 patients on hemodialysis and 30 renal transplanted patients and results were compared with 30 healthy persons (control group). In addition, plasma level of cyclosporine was measured for renal transplanted patients. Our results showed elevation in the serum levels of triglycerides, MDA and decrease in the serum levels of total antioxidant among the patients (P<0.001). In addition, serum levels of magnesium in hemodialysis patients was higher, while it was lower in renal transplant patients (P<0.01). Finally, Serum albumin levels were significantly lower in all patients. Regression analysis showed a positive correlation between triglycerides and MDA, triglycerides and total antioxidant. In addition, there was a negative correlation between Mg and cyclosporine level among renal transplanted patients. In conclusion, magnesium has beneficial effects on lipid metabolism, lipid peroxidation and increases antioxidant capacity. Present results demonstrated that cyclosporine is the most important cause of hypomagnesaemia in renal transplanted patients, so the use of cyclosporine must be considered with caution and oral magnesium supplement should be used for these patients, when cyclosporine recommended. In addition, low levels of antioxidant detected among the patient groups, suggest that prescription of oral antioxidant such as vitamin C and E could reduce the risk of arteriosclerosis in these patients.

 
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