Paper Information

Title: 

EFFECT OF CIMETIDINE ON MYOGLOBINURIC ACUTE RENAL FAILURE IN RAT

Type: POSTER
Author(s): MOROVATI H.,NAJAFZADEH H.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Acute renal failure can produce by iron released from muscles. Cytochrom P450 may be modulated this effect, thus inhibition of this enzyme may decrease renal toxicity. At this study effect of cimetidine (as inhibitor) was evaluated.
Methods: The study was done in 4 groups of rats as following: 1.Control group received saline. 2. Rats received glycerol (50%) intramuscularly. 3. As 2 and cimetidine was injected 150mg/kg 30 min before glycerol. 4. As 2 and cimetidine was injected 100mg/kg-daily for 4 days before glycerol. Rats were euthanized 24 hr after administration of glycerol, and renal removed. Proximal tubules were microscopically examined by H&E coloring.
Results: Mean of necrotic cells in group 1was significantly greater than group 2 (p=0.001). This mean in group 3 and 4 was significantly lesser than group 2, but not differ between group 3 and 4.
Conclusion: This study showed that the cimetidine can reduce myoglobinuric acute renal failure.

 
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