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Paper Information

Title: 

PREVENTIVE EFFECT OF TOTAL EXTRACT AND ETHYL-ACETATE FRACTION OF NIGELLA SATIVA ON RENAL STONE IN THE RAT

Type: POSTER
Author(s): ZABIHI N.,KHAJAVIRAD A.,HAJZADEH M.R.,MONAVAR N.,RAKHSHANDEH H.,AYAT ELAHI H.,MOHAMMADIAN N.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Renal stones are common, and prevalence has been rising in both sexes. However, there is no effective therapeutic approach for this disorder. Nigella sativa has been known as a medicinal plant against kidney stones. This study was designed to investigate the effect of total extract and ethyl-acetate fraction of Nigella sativa on calcium oxalate renal stone in the rat.
Method: Forty male Wistar rats were assigned at random to five groups including healthy control, control with ethylen glycol 1% (EG) and prevention groups that received total extract, ethyl-acetate fraction and ethyl-acetate phase remnant. Total extracts and ethyl-acetate fraction of Nigella sativa were prepared according to conventional methods. All groups except healthy control rats treated over a 28 day period with EG1%, 250mg/kg of total extract or equivalent amount of fractions. Urine and blood samples were collected from animals at days 0, 14, 28 and 0, 28, respectively. Calcium, magnesium, oxalate and citrate concentrations were measured by using commercial kits. At the end of study, kidneys were removed for histopathology examination.
Results: Calcium oxalate crystals significantly increased in EG control group (P
<0.001) compared with healthy control rats. Crystals showed a significant reduction in groups received total extract (P<0.05) or ethyl-acetate phase remnant (P<0.001) compared with EG group. However, there was no significant difference in crystals between EG and ethyl-acetate fraction groups.
Conclusion: These data support the inhibitory action of Nigella sativa on calcium oxalate kidney stone disease.

 
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