Paper Information

Title: 

ASSESSMENT OF PLASMA VITAMIN E LEVELS IN HD PATIENTS

Type: POSTER
Author(s): SEYFI B.,KADKHODAEI M.,ZAHMATKESH M.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Vitamin E is known to act as a chain breaking antioxidant that prevents the propagation of free radical reactions. This vitamin has been proved to be effective in preventing lipid peroxidation and the other radical-driven oxidative events. The risk of cancer is high in hemodialytic (HD) patients. In this study, to investigate the oxidative stress (OS) status in Iranian hemodialytic patients, we evaluated plasma vitamin E levels.
Methods: 20 hemodialytic patients and 20 control subjects (age and sex matched) were included in this study. Each patient was under dialysis, three times per week, four hours in each session. Before and after dialysis, blood was taken for biochemical analysis as well as vitamin E measurements.
Results: The level of vitamin E was significantly lower in the hemodialytic patients compared to the control group (25.94±1.87µmol/l, p<0.05) There was no significant difference after hemodialysis (21.42±1.72 vs. 21.25±1.62 µmol/l, P<0.05) in comparison to predialysis vitamin E levels.
Conclusion: In our study, the vitamin E levels were lower in patients, both pre- and post-dialysis, comparing to control subjects while there was no differences between pre- and post- dialysis levels. This may be suggestive of an oxidative stress status resulting in reduced antioxidant levels. Antioxidant therapy could be considered in these patients.

 
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