Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Title: 

THE EFFECTS OF METHANOLIC AND OILY EXTRACTS OF NIGELLA SATIVA SEED ON CALCIUM OXALATE KIDNEY STONES IN RAT

Type: POSTER
Author(s): RAHMANI Z.*,HAJZADEH M.A.R.,MOHAMMADIAN N.
 
 *DEPT. OF PHYSIOLOGY, MEDICAL SCHOOL, MUMS, MASHHAD
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

The incidence of urinary stones is very high in population. Treatment of patients with kidney stones in primary stages can reduce the side effects and may reduce the surgical operations and postoperative complications.
The aim of this study is to investigate the effects of the methanolic and oily extracts of nigella sativa (N.S) seeds on kidney stones in rat. In this study 70 Wistar rats weighed 190
±20g were randomly divided into 7 groups. Group A was received tap drinking water and group B and other groups were received 1% ethylene glycol in drinking water for 28 days. Furthermore group C was also treated with 250 mg/kg. B.W N.S methanolic extract for 28 days, while group D was also treated with 250mg/kgb.W N.S extract from the 15th day through the end of the experiment. Groups E and F were treated with 1ml/day of oily extract of N.S for 28 and 14 days respectively. Group G was also treated with 1ml/day of olive oil for 28 days. kidnies were removed and slides were prepared by routine histological techniques and examined under light microscop for detection of calcium oxalate deposits. The results showed that the number of calcium oxalate deposits were significantly increased in group B vs A (P<0.001). The number of deposits in group C was significantly lower (P<0.05) than group B but were not different from group A. The data of this study demonstrate that renal calcium oxalate crystals are reduced significantly by methanolic extract of N.S. Therefore it may have beneficial effects in treatment of urinary stones in patients.

 
Keyword(s): 
 
 
Yearly Visit 52   tarjomyar
 
Latest on Blog
Enter SID Blog