Use of chichony for treatment of goats has been explained, thus, in this study effect of indometacin and chichory on tubular excretion of phenol red in rats was compared.
In group 1, phenol red was injected intravenously; then, their serum concentration was measured after 30, 60, 180 min, by spectrophotometer. In group 2, hydroalcholic extract of chichory leaves was injected intrapritonealy. In group 3, indometacin was orally administrated. Then, phenol red was injected and measured as group 1. The mean of phenol red concentration in serum of group 2 was increased. In comparison to group 1. this effect was not seen by indometacin group 3. Thus, chichory may competitate with phenol red and decrease its tubular active excretion and chichory many uricosuric effect.