Paper Information

Title: 

THE EFFECTS OF AQUEOUS AND ETHANOLIC EXTRACTS OF PLANTAGO LANCEOLATA ON SKIN BURNED IN RAT

Type: POSTER
Author(s): HESANI J.,HAJZADEH M.A.R.,TABATABAEI A.,RAKHSHANDEH H.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Burn wounds are among the very serious illnesses of human beings with high morbidity and mortality. Products from herbal medicine have been widely used for treatment of burn wounds. Plantago Lanceolata as a medicinal plant has several effects such as: anti-septic, anti-viral, anti-toxic, anti-histaminic, anti – inflammatory and anti-rheamatic. The effects of aqueous and ethanolic extracts of Plantago Lanceolata on burn wounds were studied in this research. Wistar Albino rats were randomly divided into 6 groups (n=8). Animals were anaesthetized by ip injection of sodium tiopenton (100mg/kg BW). The back skin was shaved bilaterally and exposed to actively boiling water for 20 seconds, resulting in third degree burns of about 30 cm2 (2×3×2.5 each side) surface area. Group A (negative control) and group B (positive control) were topically treated twice daily with normal saline and silver sulfadiazine (SSD) ointment respectively; groups C and D were treated respectively with 5% and 10% of aqueous extract while groups E and F were treated respectively with 5 and 10% ethanolic extract for 14 days. Slides were prepared from burned surface areas with routine hishological methods and were examined under light microscope. Epithelialization, granulation, inflammation and fibrotic tissues were detected and expressed in a semi- quantitative scale. Data were expressed as Mean±SEM and were analyzed. The results demonstrated that the skin burned surface area and inflammation were significantly reduced with 10% aqueous extract. Repairement of epidermal tissue and hair follicles only were demonstrated in animals treated with 10% aqueous extract.
In conclusion: The results of this study showed that 10% aqueous extract of Plantago Lanceolata have inhibitory effects on inflammation and improving effects on both epithelialization and granulation. Therefore, it may have beneficial effects on burned wounds and might be used in human burned injuries

 
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