Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Title: 

ROLE OF 17-BETA ESTRADIOL ON BAROREFLEX SENSITIVITY BY AUTONOMIC SYSTEM IN FEMALE RATS

Type: POSTER
Author(s): MOHAGHEGHI A.,POURSHANAZARI A.,SOLTANPOUR N.,AMINI F.,KHATAMI F.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Estrogens (17-beta estradiol) are thought to play an important cardiovascular protective role and NTS is one of the brain areas that is important in regulation of heart function and circulation. In this study effect of estrogen on baroreflex sensitivity in Nucles Tractus Solitarii (NTS) through autonomic tone in femals rats was evaluated.
Method: This was an experimental-interventional study performed on 32 WISTAR rats weighting 250±20gr. After introduction of anesthesia ovariectomy and capsulation was happened. 2 week later, each femoral artery and vein cannulated to recorded mean artrial blood pressure (MAP) and heart rate (HR), also for infusion of phenylephrin (as a vasoconstrictor). Then NTS was exposed and drugs (Propranolol, Atropin, Salin) with micro injection have injected into the NTS. We used Clab Instrument for baroreflex sensivity (BRS) index (Δ HR/ Δ MAP) and the statistic method were t. test & ANOVA.
Results: Estrogen in acute hypertension state enhanced reflex "p<0.05. BRS in estrogen received group was significantly more than control group, "p<0.01". BRS in estrogen receiving group and control group decrease significantly after the micro-injection of Atropin compared with the micro-injection of Saline or Propranolol in rats.
Conclusion: It is concluded that estrogen in acute hypertension state in NTS is more effective through parasympathetic system on BRS and this can be useful in HRT/ERT.

 
Keyword(s): 
 
 
Yearly Visit 35   tarjomyar
 
Latest on Blog
Enter SID Blog