Paper Information

Title: 

STATUS OF C-REACTIVE PROTEIN IN ACUTE CORONARY SYNDROME

Type: POSTER
Author(s): TAHIR A.,MUNIR M.,NASIR AFZAL -
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Inflammation plays a key role in the initiation and progression of atherosclerosis, the most common cause of acute coronary syndrome (ACS). C-reactive protein (CRP) that enhances plaque inflammation is synthesized six hours after myocardial infarction.
Objectives: To determine the hsCRP levels in patients with ACS and to compare its levels between patients on conservative and interventional management.
Methods and Results: hsCRP was measured by Immunoturbidimertric method in 50 controls and 100 patients of ACS on conservative or interventional management. Serum CRP levels [mg/L±SEM] at the time of admission were significantly raised in patients of ACS (11.9±2.3) as compared to controls (2.3±0.178) and further increased progressively during 24 hours of follow up period. CRP levels also increased significantly in patients who underwent interventional management (115.9±7.73) as compared to those who were on conservative management (22.28±5.54).
Conclusion: Serum CRP levels were found to be sgnificantly raised in patients with ACS as compared to controls. In addition, patients undergoing interventional management had higher CRP levels, post intervention, as compared to those on conservative management.

 
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