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Paper Information

Title: 

IN-VITRO STUDY OF ANTI-CARCINOGENIC EFFECT OF CONFERONE ON CARCINOMA NTERA2 CELLS

Type: POSTER
Author(s): NESHATI V.,MOGHADAM MATIN M.,BAHRAMI A.R.,MOGHIMI A.,BEHRAVAN J.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

NTERA2 cells are pluripotent embryonal carcinoma cells and derived from human germ cell tumors. These cells have a very high proliferative potency and they are suitable for anticarcinogenic evaluation. In the present research the cytotoxic effect of conferone was investigated on NTERA2 cells. Conferone is extracted from the Ferula schtschurowskiana (Apiaceae family). After finding the effective dose of this substance on NTERA2 cells, the growth curve of carcinoma cells was drawn. Then MTT assay, which is based on the functional feature of mitochondrial enzymes was used to determin the cytotoxic effects of conferone and the level of Oct4 mRNA, which is a marker of undifferentiated cells was studied.

 
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