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Paper Information

Title: 

BRONCHODILATORY EFFECT OF CARUM COTPTICUM COPTICUM IN ASTHMATIC PATIENTS

Type: POSTER
Author(s): YAVARI F.,SALIMINEZHAD L.,BOSKABADI M.H.,ALIZADEH A.,JAHANBIN B.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Several therapeutic effects including anti-asthma and dyspnea have been described for the seeds of Carum copticom. In this study, the bronchodilatory effect of the boiled extract of Carum copticum in the airways of asthmatic patients was examined.
Methods: The bronchodilatory effects of 0.125 and 0.25ml/kg of 10g% boiled extract and 6 mg/kg theophylline ware studied by measuring forced expiratory volume in one second (FEV1), peak expiratory flow (PEF), maximal pulmonary function tests (PFTs) 30, 60, 90, 120 150, and 180min after administration.
Results:
Boiled extract of Carum copticum caused significant increases in all measured pulmonary function tests (PFTs), in most time intervals, (p<0.05-p<0.001). The difference of increase in MMEF, MEF75, MEF25 and sGaw due to administration of both doses of boiled extract with the effects of theophylline were only significant in last time intervals (p<0.01 to p<0.01). The onset of brochodilatory effect of extract was similar to that of theophyline begining 30min and the effect of extract decline after 150 min after administration similar to the effect of theophylline.
Conclusion: showed that Carum copticum has a relatively bronchodilatory effect on asthmatic airways which was comparable with the effect of theophylline at concentrations used. on tracheal chains, a relatively potent bronchodilatory effect on asthmatic airways and a potent antitussive effect.

 
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