Paper Information

Title: 

ASTHMA SYMPTOM REDUCTION WITH PURPLE PASSION FRUIT PEEL EXTRACT

Type: POSTER
Author(s): FARID HOSSEINI R.,WATSON R.,ZIBADI SH.,JABARI FARHAD,GHAFARI J.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Asthma, affecting as many as 400 million individuals worldwide. The number of patients suffering from asthma, especially children, is dramatically increasing. In addition the frequent inability of conventional therapies is being sought. Asthma is characterized as a chronic inflammatory process. These studies were undertaken to investigate the efficacy of the purple passion fruit peel (PFP) extract -a mixture of bioflavonoids, phenolic acids, and anthocyanins- know to scavenge free radicals while possessing antioxidant and anti-inflammatory actions. The objective of this study was to evaluation the efficiency of this agent in randomized, double -blinded, placebo-controlled study in adult patients with moderate to severe asthma.
Methods: The PFP extract was studied in 16 women and 8 men (age 15-60 year) subjects with a four-week randomized, double blind, placebo-controlled trial with administration of oral PFP extract (150 mg/day) or placebo pills. The effects of PFP extract were evaluated by measuring clinical symptoms of asthma.
Results: Most clinical symptoms of asthma of subjects supplemented with the PFP extract were moderated significantly compared to those taking placebo. The proportion of patients having wheeze, cough, as well as shortness of breath was reduced significantly by PFP while the placebo caused no significant reduction .The 1-second forced vital capacity expired air and peak expiatory of those supplemented were increased significantly by PFP while controls were not changed. Patients fed the PFP extract reported no significant adverse effects.
Conclusion: The purple passion fruit peel extract may be safely offered to asthmatics as an alternative treatment option to reduce clinical symptoms.

 
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