Paper Information

Title: 

NANOBIOTECHNOLOGY AND DRUG DELIVERY SYSTEMS

Type: SPEECH
Author(s): ROUH ALAMINI NAJAFABADI A.A.H.,FIROUZPOUR A.,RAHIMI A.A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Nanoparticles have been developed as an important strategy to deliver conventional drug, recombinant protein, vaccines, and other biomolecules. Nanopatticles are tiny material (<1000nm in size) that have specific physiochemical properties different to bulk material of the same composition and such properties make them very attractive for commercial and medical development. Application of nanoparticles and nanomaterials for the diagnostic and therapeutic purpose is now significantly extended in nanomedicine. Use of Nanobiotechnology approach and nanomaterials open new prospects for creation of drug and system for their directed transport. Delivery of these molecules to specific areas with the body can be achieved, which will reduces systemic side effects and allow for more efficient use of the drug. Polymeric nanoparticles have demonstrated enormous potential as cellular drug delivery vehicles. The potential of drug delivery system based on the use of nanoparticles from significant advantage such as: (i) the ability of target specific location in the body; (ii) the reduction of the quantity of drug needed to attain a particular concentration in the vicinity of the target; and (iii) the reduction of the concentration of the drug at nanotarget size minimizing severe side effect, and also cellular drug delivery using nanoparticles is also affected by clearance through the reticuloendothelial system. Nanoparticles including dendrimers (3-5nm), micelle (5-10nm), emulsion (100-150nm), nano particulates system (20-150nm) and liposome (100-150nm) are used to target specific area in the body. The nanoprticles must be endow with characteristic needed to reach a given target, which means attaining a suitable combination of nature, size, way of conjugating the drug to the NP (attach, absorbed, encapsulated), surface chemistry, hydrophilicity/hydrophbicity, surface functionalization, biodegradability, and physical response properties (temperature, PH, electric charge, light, sound, magnetism).

 
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