Paper Information

Title: 

ORAL MORPHINE ADMINISTRATION LEAD TO DELAY ON NEURAL SYSTEM DEVELOPMENT IN RAT EMBRYO

Type: POSTER
Author(s): NASIRI MOGHADAM SH.,FEREYDOUNI M.,BAHADORAN H.,AHMADIANI A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Morphine abuse during pregnancy may result in abnormal nervous system function. We reported that maternal morphine consumption in 3 doses (0.1, 0.05, 0.01mg/ml) can lead to delay on neural tube development in embryonic day 9.5 (E 9.5) and lower lose was more effective. In order to evaluate the effects of morphine on the development of the nervous system, the present study focused on the effects of maternal morphine administration on the other sections of neural system development on neural plate, neural tube and optic vesicles development in wistar rat embryos.
Methods: Embryonic days 8.5 to 11.5 were selected for the study. Female wistar rats (200-250g) were crossed (embryonic day0-E0). Experimental groups received 0.01 mg/ml of morphine in drinking water daily (15 ml water for each rat).Control group received tap water. On embryonic days 8.5, 9.5, 10.5, 11.5, the animals were anesthetized and the embryos were surgically removed. The embryos were fixed in 10% formalin for 1 week, and then tissues were processed, sectioned, and stained in hematoxylin and eosin.
Result: The sections were investigated for alteration in nervous system development induced by maternal morphine treatment using light microscope and Digi3 software. It seems that daily consumption of morphine sulfate could delay in neural system (neural plate, neural tube and optic vesicle).
Conclusion: regard to the results, it seems that morphine usage can change neural system development but molecular mechanisms by which morphine can induce such alteration remained to be clarify. These defects might affect on the latest sections of neural system such as cerebrum, cerebellum, spinal cord and the behavior of the animals which are needed to investigate more.

 
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