Paper Information

Title: 

THE INTERACTION OF ANGIOTENSINERGIC AND α1-ADRENERGIC SYSTEM ON WATER INTAKE IN ADULT MALE WISTAR RATS

Type: POSTER
Author(s): NAVAEIAN M.*,ORYAN SHAHRBANOU,ZARINDAST M.R.,PAKPOUR B.
 
 *BIOLOGY DEPARTMENT, ISLAMIC AZAD UNIVERCITY OF SHAHRE-REY (YADEGAR E EMAM), TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Water intake is under control of mechanisms which are still fully unclear. Angiotensin II plays a key role in the fluid homeostasis regulation. This neurotransmitter has an excitatory effect on water intake. How specific is the excitatory action of Angiotensin II on fluid intake, remain a question to be answered. Angiotensin II receptors are expressed in some papulation of neurons originating from Subfornical Organ and OVLT. a 1- adrenergic system have an important role in water intake mechanisms. In this study, the interaction of i.c.v injection of captopril and a1-adrenergic agents in water deprived rats were investigated. For i.c.v. administration, a guide cannula was implanted in the right lateral ventricle of the adult male wistar rats, weighing between 200-250g. After recovery period, animals deprived of water for 24 h and the drogs were injected. Then rats were free to drink for 1 h and the volume of water intake was measured. The result showed that captopril (7µg/rat), the angiotensin. Converting enzyme inhibitor (ACEI), and phenylephrine (0.5µg/rat), the α1-adrenergic reseptor agonist decresed water intake, while prazosine (0.25µg/rat), the a1-adrenergic receptor antagonist increased this response in isolated rates. Blockade of central angiotensin converting enzyme by captopril attenuate the inhibitory and excitatory effects of phenylephrine and prazosine. The present data indicated that angiotensinergic and a1-adrenergic system have a close interaction in the water intake mechanisms.

 
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