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Paper Information

Title: 

PARAOXON-INDUCED CHANGES OF CASPASE ACTIVITY IN RAT CULTURED HIPPOCAMPAL CELLS IN NB/B27

Type: POSTER
Author(s): YOUSEFPOUR M.,BAHRAMI F.,JAFARI M.,KHOUSHBATEN A.,ASGARI A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

There are two known types of cell death, necrosis and apoptosis that differ in the cause, histology and morphology; both caused by either intrinsic or extrinsic factors. paraoxon is an insecticide organophosphate that can induce cell death. In present study, we used Caspase activity assay to identify the type of cell death induced by Paraoxon in hippocampal cells cultured in neurobasal/B27 medium. Cells were derived from brain of Wistar neonatal rats and studied in two groups (24hrs and one week exposure time) exposed to 50 and 100µM paraoxon. In the end of the week, we assayed Caspase activity in both groups. The results indicate that there are no changes in Caspase activity. The comparison of these data with results obtained from Hoechst staining shows that in this condition, paraoxon cannot induce apoptosis in hippocampal cell culture.

 
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