Paper Information

Title:  INFLUENCE OF BLOCKADE OF VENTRAL HIPPOCAMPAL NMDA RECEPTORS ON MORPHINE-INDUCED ANXIOLYSIS
Type: POSTER
Author(s): MOTEVASELI T.,REZAYOF A.,RASOULI Y.,ZARINDAST M.R.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Some reports indicate that morphine can induce anxiolytic effects in laboratory animals. In the present study, the effects of bilateral injections of the NMDA receptor antagonist, DAP-5 into the ventral hippocampus on morphine-induced anxiolysis in mice, using elevated plus-maze were investigated.
Methods: Animals were bilaterally cannulated in the ventral hippocampus by stereotaxic instrument, and were allowed to recover 1-week before behavioral testing (EPM). The elevated plus maze (EPM) is one of models for the selective identification of anxiolytic or anxiogenic drug effects in rodents.
Results: Subcutaneous injections of the different doses of morphine (3, 6 and 9mg/kg) increased the percentage of open arm time (%OAT) and open arm entries (%OAE) in the EPM, indicating that morphine produced a significant anxiolytic behavior. Intra-ventral hippocampal administration of the NMDA receptor antagonist, DAP-5 (0.5, 1 and 2μg/mouse), 5 min before morphine (9 mg/kg) injection decreased the percentage of open arm time (%OAT) and open arm entries (%OAE) and thus this pre-treatment inhibited the morphine-induced anxiolysis. While, bilateral injections of different doses of DAP-5 into the ventral hippocampus by itself did not alter %OAT and %OAE.
Conclusion: The present data demonstrate that morphine induces anxiolytic-related behavior in the EPM. Furthermore, these findings implicate the involvement of a glutamatergic mechanism in morphine-induced anxiolysis through the NMDA receptors of the ventral hippocampus.

 
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