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Paper Information

Title: 

KETAMIN INDUCES ANTEROGRADE AMNESIA IN RATS

Type: POSTER
Author(s): MEHRABINASAB E.*,NEDAEI S.E.,POURMOTABED ALI,TOUHIDI A.
 
 *DEPT. OF PHYSIOLOGY, SCHOOL OF MEDICINE, KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES, KERMANSHAH, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: the NMDA receptors, which have been implicated in memory formation, could be noncompetitively blocked by ketamin. Present study examines the short term effect of ketamine on induction of anterograde amnesia in male rats using Morris water maze (MWM).
Methods: in the current study 30 male N-MRI rats (170-220g) were divided into five experimental groups, randomly. Animals were tested in MWM for 7 consecutive days to examine anterograde amnesia processes. Rats received daily injection of ketamine (0, 1, 3, 6, or 12mg/kg/ip) 10 min before examination from day 1 to 6. Relevant vehicle also administered before retrieval trial on day 7. Spatial learning and memory parameters were recorded and subjected to the t.test and ANOVA. Difference was considered significant if p<0.05.
Results: data showed significant dose dependent reduction in learning and memory processes in Ketamin treated rats with respect to control ones.
Conclusion: it can be concluded that ketamin induced anterograde amnesia in rats.

 
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