Paper Information

Title: 

EFFECT OF LOW FREQUENCY STIMULATION OF PERFORANT PATH ON KINDLING RATE AND SYNAPTIC TRANSMISSION IN THE DENTATE GYRUS IN RATS

Type: POSTER
Author(s): MOHAMMADZADEH M.,MIRNAJAFIZADEH S.J.,FATH ELAHI Y.,JAVAN M.,GHORBANI P.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Kindling development and potentiation of synaptic neurotransmission due to kindling can be reversed by Low Frequency Stimulation (LFS). In the present study the effect of LFS of the perforant path on seizure development induced by rapid perforant path kindling was investigated.
Methods: Animals were kindled by electrical stimulation of perforant path. One group of animals received LFS (0.1 ms pulses at 1 Hz, 200 pulse, and 50-150 µA) immediately after termination of each kindling stimulations. Basal field potential recording and paired pulse stimulations were done before kindling stimulations every day.
Results: Application of LFS significantly retards the kindling acquisition and suppressed the progression of seizure stages. LFS also prevented from increment of slope of field excitatory postsynaptic potentials and population spike amplitude during kindling. LFS had no significant effect on increment of early paired pulse depression (at the inter-pulse interval of 10-50 ms) during kindling, but it significantly reduced the marked potentiation of late paired pulse depression induced by kindling.
Conclusion: According to these results, it may be suggested that LFS of perforant path has a significant antiepileptogenic effect. This effect may be through presynaptic inhibition of the perforant path-granular cells synapses that causes decrease of dentate gyrus firing and activity of inhibitory interneuron.

 
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