Paper Information

Title: 

STUDY OF EFFECT OF NIMODIPINE ON FORMALIN-INDUCED PAIN IN MICE

Type: POSTER
Author(s): MAHMOUDI J.,KHAYAT NOURI M.H.,HOSSEINCHI GHARAGHAJI M.R.,GOLABI M.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Voltage-gated calcium channels play a major role in the control of cellular processes in cardiac, vascular and neuronal tissues. Although the importance of these channels in nociception is not clearly established. A number of studies have been shown that calcium channel blockers have antinociception effects in a range of animal models (but not all animals). The aim of this study was to investigate the effect of nimodipine on formalin-induced pain in mice.
Method: nimodipine (10 mg/kg) was intraperitoneally injected 30 minute before intrapawly formalin (20µL, 5%) injection. The time of licking and bitting of injected paw was measured as pain response at 5 min bins for 1 hour.
Results: The results showed that formalin-induced a biphasic pain response (first phase: 0-5 and second phase: 40-10 minute after injection). Intraperitoneally injection of nimodipine before formalin reduce the second phase of pain response significantly (P<0.05. and not significantly effect on first phase (P<0.05).
Conclusions: In Conclusion our results suggested that the nimodipine possess antinociceptive activity probably via a decrease in Ca2+ influx that in turn interferes with the release of neurotransmitters and other substances that promote nociception and inflammation.

 
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