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Paper Information

Title: 

EFFECT OF AQUEOUS EXTRACT OF VALERIAN OFFICINALIS ROOT ON PTZ-INDUCED SEIZURE IN MICE

Type: POSTER
Author(s): NAMVARAN A.,KHAYAT NOURI M.H.,GOLABI M.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Phamacognostic studies shown that the root of valerian officinalis (VO) contains gamma-amino butyric acid and other materials. In traditional medicine anticonvulsant effect of VO is reminded. A number of studies have been shown that this herb has anticonvulsant and hypnotic effects in a range of animal seizure models but not all animals. The aim of this study was to investigate the effect of aqueous extracts of VO on PTZ-induced clonic seizure threshold in mice.
Methods: After determination of the intravenously PTZ-induced seizure threshold in control group, extract of valerian officinalis root (0.25, 0.5 and 1g/kg) orally administration and investigate the effects of VO on clonic seizure threshold.
Results: Our results shown that the PTZ-seizure threshold was in control group in animals pretreated with VO the PTZ seizure threshold dose dependently increased, significantly (P<0.05).
Conclusions: Our results suggest that VO posse's.

 
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