Paper Information

Title: 

THE COMPARISON BETWEEN EFFECT OF SHORT-TERM AND MID-TERM EXERCISE ON THE ENTHUSIASM OF THE MALE RATS TO SELF-ADMINISTER MORPHINE

Type: POSTER
Author(s): NADERI A.*,ALAEI H.A.,SHARIFI M.R.,HOSSEINI M.
 
 *DEPARTMENT OF PHYSIOLOGY, MEDICAL UNIVERSITY OF ISFAHAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Objective: Several neurotransmitters may involve in addiction. Exercise can activate the same pathways as morphine. This research study the effect of short-term and mid-term exercise on the enthusiasm of the male rats to self- administer morphine.
Methods: After training rats to receive food by pressing the active lever Jugular vein was cannulated and rats were divided into 4 groups: Saline, Morphine, Exercise 1(11day) and Exercise 2 (30day). The animals were placed in the self- administration apparatus 2 hours a day for 11 days after 90- minute exercise. The animals received 0.1 ml of morphine together with food in first 6 days and only 0.1 ml of morphine in the later 5 days by pressing the active lever while receiving no food at the time. A computer recorded the number of active as well as passive lever pressing which finally enabled a full comparison between the number of active and passive lever pressing in each group and the number of active lever pressing among all four groups.
Results: The number of active lever pressing in Saline group was more than the passive lever within the first 8 days (p<0.05).However during the last 3 days no significant difference could be observed between the number of active lever pressing. In the Morphine group the number of active lever pressing was significantly rather than the passive lever all through the 11 days.(p<0.05). Besides , in the last 3 days the number of the active lever pressing by Morphine group was significantly higher than that of the Saline group. The number of active lever pressing in exercise group 1 and 2 was significantly lower than the Morphine group.
Discussion: As exercise can activate many neurotransmitters systems involved in the addiction process and increase the release of endorphins. It is likely, that this way, it could decrease the rats’ tendency to morphine.

 
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